Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog

Edward Neuwelt, E. P. Frenkel, S. Rapoport, P. Barnett

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Infusion of 25% mannitol into the internal carotid od the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetration of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotrexate levels were maximized by giving this chemotherapeutic drug by the intracarotid rather than the intravenous route after osmotic BBB disruption, Assays of MTX levels in cerebrospinal fluid were found to be a very unreliable and inconsistent monitor of brain MTX levels after osmotic BBB disruption.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalNeurosurgery
Volume7
Issue number1
StatePublished - 1980
Externally publishedYes

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Blood-Brain Barrier
Methotrexate
Pharmacokinetics
Dogs
Brain
Cerebrum
Mannitol
Cerebrospinal Fluid
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog. / Neuwelt, Edward; Frenkel, E. P.; Rapoport, S.; Barnett, P.

In: Neurosurgery, Vol. 7, No. 1, 1980, p. 36-43.

Research output: Contribution to journalArticle

Neuwelt, E, Frenkel, EP, Rapoport, S & Barnett, P 1980, 'Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog', Neurosurgery, vol. 7, no. 1, pp. 36-43.
Neuwelt, Edward ; Frenkel, E. P. ; Rapoport, S. ; Barnett, P. / Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog. In: Neurosurgery. 1980 ; Vol. 7, No. 1. pp. 36-43.
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