Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog

E. A. Neuwelt, E. P. Frenkel, S. Rapoport, P. Barnett

Research output: Contribution to journalArticle

58 Scopus citations


Infusion of 25% mannitol into the internal carotid od the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetration of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotrexate levels were maximized by giving this chemotherapeutic drug by the intracarotid rather than the intravenous route after osmotic BBB disruption, Assays of MTX levels in cerebrospinal fluid were found to be a very unreliable and inconsistent monitor of brain MTX levels after osmotic BBB disruption.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
Issue number1
StatePublished - Jan 1 1980


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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