Effect of oral contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity

Bliss Kaneshiro, Alison Edelman, Chandravanu Dash, Jui Pandhare, Faapisa M. Soli, Jeffrey T. Jensen

Research output: Contribution to journalArticle

2 Scopus citations


Objectives To describe the effect of combined oral contraceptives (COCs) on matrix metalloproteinases MMP-2 and MMP-9 activity and compare MMP activity in women taking a COC with or without doxycycline. Study design Subjects (n= 20) underwent endometrial biopsies (1) in the late luteal phase of a baseline cycle prior to initiating COCs, (2) on days 19-21 while taking COCs in a standard 28-day cycle (7-day hormone-free interval) and (3) on days 26-28 while taking active COCs continuously for a 28-day cycle. During the continuous COC cycle, they were randomized to receive daily subantimicrobial dose doxycycline 40 mg or placebo. Results Compared to baseline, COC treatment increased MMP-2 (p

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
Issue number1
StatePublished - Jan 1 2016


  • Combined oral contraceptives
  • Doxycycline
  • Endometrial biopsy
  • Matrix metalloproteinase-2 (MMP-2)
  • Matrix metalloproteinase-9 (MMP-9)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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