Effect of morphine on the transport of dopamine into mouse brain slices

R. J. Hitzemann, H. H. Loh

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Abstract

The effect of various concentrations of morphine on the transport of dopamine (DA) into slices from the mouse brain cortex and diencephalon was investigated. It was observed that sub-analgetic levels of morphine, 3.5 × 10-8M, produced mixed inhibition in the cortex and uncompetitive inhibition in the diencephalon. When the concentration of morphine was increased to within the therapeutic range (3.5 × 10-6), a greater effect on DA affinity rather than reaction velocity was observed in the cortex although the inhibition remained mixed. Only the increase in inhibition of DA transport observed by increasing the morphine concentration from 3.5 × 10-8 to 3.5 × 10-6 M was blocked by the morphine antagonist naloxone. Increasing the morphine concentration in the diecephalon changed the type of inhibition from uncompetitive to mixed kinetics.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalEuropean Journal of Pharmacology
Volume21
Issue number2
DOIs
StatePublished - Feb 1973

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Keywords

  • Catecholamine transport
  • Dopamine
  • Morphine

ASJC Scopus subject areas

  • Pharmacology

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