Effect of methylxanthine derivatives on T cell activation

J. W. Singer, J. A. Bianco, G. Takahashi, C. Simrell, J. Petersen, D. F. Andrews

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In a Phase I-II trial examining the effect of prophylactic administration of pentoxifylline (PTX) on bone marrow transplant-associated morbidity, there was an apparent reduction in the incidence and severity of acute graft-versus-host disease. To determine if PTX might be directly immunosuppressive, its effects on T cell activation and proliferation were examined. PTX and several cogeners were found to directly suppress T cell proliferation in response to phytohemagglutinin, to allogeneic cells in a mixed leukocyte reaction, and to cross-linking the CD3 complex. The effects were dose-related and associated with suppression of secretion of tumor necrosis factor-α (TNFα). However, the inhibition of proliferation was not solely due to this effect since adding excess recombinant TNFα did not restore the proliferative response. These data suggest that PTX may be clinically useful in suppressing allogeneic reactions in bone marrow transplantation.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalBone marrow transplantation
Volume10
Issue number1
StatePublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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