Effect of low doses of estradiol on 6-month growth rates and predicted height in patients with Turner syndrome

Judith Levine Ross, Lauren Myerson Long, Marilyn Skerda, Fernando Cassorla, David Kurtz, D. Lynn Loriaux, Gordon B. Cutler

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


We randomly assigned 16 girls with Turner syndrome, age 5 to 15 years, to receive treatment with 100 ng/kg/day ethinyl estradiol or placebo for 6 months, with crossover after a 2-month interim period. We assessed growth by measurement of the 4-week lower leg growth rate and by height velocity. Bone age was determined at the beginning and end of treatment. Growth rate during ethinyl estradiol treatment was approximately 70% greater than during placebo (P <0.001), without any bone age advancement relative to that with placebo. The change in predicted height was significantly greater after 6 months treatment with ethinyl estradiol than after treatment with placebo (mean±SEM, +0.35±0.38 cm vs. -0.85±0.32 cm, P<0.03). Breast budding occurred in six patients. We conclude that it may be feasible to begin low-dose estrogen therapy to promote growth at an earlier age than would be conventionally used to induce pubertal development. These data are still relatively short term, however; until long-term data are avallable, it would be premature to make definitive recommendations regarding the dose and timing of estrogen treatment in Turner syndrome.

Original languageEnglish (US)
Pages (from-to)950-953
Number of pages4
JournalThe Journal of pediatrics
Issue number6
StatePublished - Dec 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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