TY - JOUR
T1 - Effect of low concentrations of apomorphine on parkinsonism in a randomized, placebo-controlled, crossover study
AU - Gunzler, Steven A.
AU - Koudelka, Caroline
AU - Carlson, Nichole E.
AU - Pavel, Misha
AU - Nutt, John G.
PY - 2008/2
Y1 - 2008/2
N2 - Objective: To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. Design: Randomized, double-blind, placebo-controlled, crossover clinical trial. Setting: Academic movement disorders center. Patients: Patients with Parkinson disease and motor fluctuations. Intervention: Fourteen patients with Parkinson disease and motor fluctuations were randomized to receive 1 of 6 possible sequences of placebo, low-dose (sub-threshold) apomorphine hydrochloride, and high-dose (threshold to suprathreshold) apomorphine hydrochloride infusions. Subthreshold doses of apomorphine hydrochloride (12.5 μg/kg/h every 2 hours and 25 μg/kg/h every 2 hours), threshold to suprathreshold doses of apomorphine hydrochloride (50 μg/kg/h every 2 hours and 100 μg/kg/h every 2 hours), and placebo were infused for 4 hours daily for 3 consecutive days. Main Outcome Measures: Finger and foot tapping rates. Results: There was no decline in finger or foot tapping rates during the low-dose apomorphine hydrochloride infusions relative to placebo. The high-dose infusions increased foot tapping (P<.001) and trended toward increasing finger tapping compared with placebo infusions. Conclusions: Subthreshold concentrations of apomorphine did not worsen parkinsonism, suggesting that presynaptic dopamine autoreceptors are not important to the motor response in moderate to advanced Parkinson disease.
AB - Objective: To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. Design: Randomized, double-blind, placebo-controlled, crossover clinical trial. Setting: Academic movement disorders center. Patients: Patients with Parkinson disease and motor fluctuations. Intervention: Fourteen patients with Parkinson disease and motor fluctuations were randomized to receive 1 of 6 possible sequences of placebo, low-dose (sub-threshold) apomorphine hydrochloride, and high-dose (threshold to suprathreshold) apomorphine hydrochloride infusions. Subthreshold doses of apomorphine hydrochloride (12.5 μg/kg/h every 2 hours and 25 μg/kg/h every 2 hours), threshold to suprathreshold doses of apomorphine hydrochloride (50 μg/kg/h every 2 hours and 100 μg/kg/h every 2 hours), and placebo were infused for 4 hours daily for 3 consecutive days. Main Outcome Measures: Finger and foot tapping rates. Results: There was no decline in finger or foot tapping rates during the low-dose apomorphine hydrochloride infusions relative to placebo. The high-dose infusions increased foot tapping (P<.001) and trended toward increasing finger tapping compared with placebo infusions. Conclusions: Subthreshold concentrations of apomorphine did not worsen parkinsonism, suggesting that presynaptic dopamine autoreceptors are not important to the motor response in moderate to advanced Parkinson disease.
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U2 - 10.1001/archneurol.2007.58
DO - 10.1001/archneurol.2007.58
M3 - Article
C2 - 18268187
AN - SCOPUS:39049096851
SN - 0003-9942
VL - 65
SP - 193
EP - 198
JO - Archives of Neurology
JF - Archives of Neurology
IS - 2
ER -