Effect of low concentrations of apomorphine on parkinsonism in a randomized, placebo-controlled, crossover study

Steven A. Gunzler, Caroline Koudelka, Nichole E. Carlson, Misha Pavel, John Nutt

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. Design: Randomized, double-blind, placebo-controlled, crossover clinical trial. Setting: Academic movement disorders center. Patients: Patients with Parkinson disease and motor fluctuations. Intervention: Fourteen patients with Parkinson disease and motor fluctuations were randomized to receive 1 of 6 possible sequences of placebo, low-dose (sub-threshold) apomorphine hydrochloride, and high-dose (threshold to suprathreshold) apomorphine hydrochloride infusions. Subthreshold doses of apomorphine hydrochloride (12.5 μg/kg/h every 2 hours and 25 μg/kg/h every 2 hours), threshold to suprathreshold doses of apomorphine hydrochloride (50 μg/kg/h every 2 hours and 100 μg/kg/h every 2 hours), and placebo were infused for 4 hours daily for 3 consecutive days. Main Outcome Measures: Finger and foot tapping rates. Results: There was no decline in finger or foot tapping rates during the low-dose apomorphine hydrochloride infusions relative to placebo. The high-dose infusions increased foot tapping (P

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalArchives of Neurology
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 2008

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ASJC Scopus subject areas

  • Neuroscience(all)

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