Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: A pilot study

Hideo Uno, Michele L. Zimbric, Daniel M. Albert, Johan Stjernschantz

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 μg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 μg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty μg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 μg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalActa dermato-venereologica
Volume82
Issue number1
DOIs
StatePublished - May 8 2002

Keywords

  • Latanoprost
  • Stump-tailed macaque hair growth

ASJC Scopus subject areas

  • Dermatology

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