TY - JOUR
T1 - Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque
T2 - A pilot study
AU - Uno, Hideo
AU - Zimbric, Michele L.
AU - Albert, Daniel M.
AU - Stjernschantz, Johan
PY - 2002/5/8
Y1 - 2002/5/8
N2 - Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 μg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 μg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty μg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 μg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.
AB - Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 μg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 μg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty μg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 μg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.
KW - Latanoprost
KW - Stump-tailed macaque hair growth
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U2 - 10.1080/000155502753600803
DO - 10.1080/000155502753600803
M3 - Article
C2 - 12013211
AN - SCOPUS:0036234441
VL - 82
SP - 7
EP - 12
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 1
ER -