We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)