Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

Tapani Vanha-Perttula, Peter Kohler, Lawrence A. Frohman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.

Original languageEnglish (US)
Pages (from-to)805-813
Number of pages9
JournalLife Sciences
Volume9
Issue number14 PART 2
DOIs
StatePublished - Jul 22 1970
Externally publishedYes

Fingerprint

Pituitary Neoplasms
Growth Hormone
Hydrocortisone
Rats
Tumors
Cells
Insulin
Thymidine
DNA

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells. / Vanha-Perttula, Tapani; Kohler, Peter; Frohman, Lawrence A.

In: Life Sciences, Vol. 9, No. 14 PART 2, 22.07.1970, p. 805-813.

Research output: Contribution to journalArticle

Vanha-Perttula, Tapani ; Kohler, Peter ; Frohman, Lawrence A. / Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells. In: Life Sciences. 1970 ; Vol. 9, No. 14 PART 2. pp. 805-813.
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