Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

Tapani Vanha-Perttula, Peter O. Kohler, Lawrence A. Frohman

Research output: Contribution to journalArticle

3 Scopus citations


We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.

Original languageEnglish (US)
Pages (from-to)805-813
Number of pages9
JournalLife Sciences
Issue number14 PART 2
StatePublished - Jul 22 1970


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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