Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

Tapani Vanha-Perttula; Peter O. Kohler; Lawrence A. Frohman

doi:10.1016/0024-3205(70)90085-8

Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

Tapani Vanha-Perttula, Peter O. Kohler, Lawrence A. Frohman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH₁ line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.

Original language	English (US)
Pages (from-to)	805-813
Number of pages	9
Journal	Life Sciences
Volume	9
Issue number	14 PART 2
DOIs	https://doi.org/10.1016/0024-3205(70)90085-8
State	Published - Jul 22 1970
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(70)90085-8

Cite this

@article{cf4a81f089a0454da93f4b24a3351e93,

title = "Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells",

abstract = "We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.",

author = "Tapani Vanha-Perttula and Kohler, {Peter O.} and Frohman, {Lawrence A.}",

note = "Funding Information: Supported by USPHS Grants 1 FOS-1282-O1 and HD-03331 .",

year = "1970",

month = jul,

day = "22",

doi = "10.1016/0024-3205(70)90085-8",

language = "English (US)",

volume = "9",

pages = "805--813",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "14 PART 2",

}

TY - JOUR

T1 - Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

AU - Vanha-Perttula, Tapani

AU - Kohler, Peter O.

AU - Frohman, Lawrence A.

N1 - Funding Information: Supported by USPHS Grants 1 FOS-1282-O1 and HD-03331 .

PY - 1970/7/22

Y1 - 1970/7/22

N2 - We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.

AB - We have studied the effect of insulin on DNA synthesis and the induction of growth hormone (GH) by cortisol in the GH1 line of rat pituitary tumor cells. Insulin alone did not increase GH production at any concentration tested. Insulin potentiated the cortisol-induced GH synthesis at physiologic doses and pharmacologic doses, but intermediate levels of insulin were inhibitory. Thymidine incorporation showed a similar biphasic response to varying insulin concentrations.

UR - http://www.scopus.com/inward/record.url?scp=0014958649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014958649&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(70)90085-8

DO - 10.1016/0024-3205(70)90085-8

M3 - Article

C2 - 5529426

AN - SCOPUS:0014958649

SN - 0024-3205

VL - 9

SP - 805

EP - 813

JO - Life Sciences

JF - Life Sciences

IS - 14 PART 2

ER -

Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this