Effect of Hypoxemia with or without Increased Placental Vascular Resistance on Fetal Left and Right Ventricular Myocardial Performance Index in Chronically Instrumented Sheep

Amar Bhide, Olli Vuolteenaho, Mervi Haapsamo, Tiina Erkinaro, Juha Rasanen, Ganesh Acharya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myocardial performance index (MPI) is increased in growth-restricted fetuses with placental insufficiency, but it is unknown if this is due to fetal hypoxemia or increased placental vascular resistance (Rplac). We used chronically instrumented sheep fetuses (n = 24). In 12 fetuses, placental embolization was performed 24 h before experiments. On the day of the experiment, left (LV) and right (RV) ventricular MPIs were obtained by pulsed Doppler at baseline and in the hypoxemia and recovery phases. At baseline, Rplac was greater and fetal pO2 lower in the placental embolization group, but RV and LV MPIs were comparable to those of the control group. During hypoxemia, mean LV MPI increased significantly only in fetuses with an intact placenta (0.34 vs. 0.46), returning to baseline during the recovery phase. Right ventricular MPI was unaffected. We conclude that fetal LV function is sensitive to acute hypoxemia. Exposure to chronic hypoxemia could pre-condition the fetal heart and protect its function with worsening hypoxemia.

Original languageEnglish (US)
Pages (from-to)2589-2598
Number of pages10
JournalUltrasound in Medicine and Biology
Volume42
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

hypoxemia
sheep
Vascular Resistance
Sheep
fetuses
Fetus
recovery
Placental Insufficiency
Fetal Heart
Placenta
Hypoxia
Control Groups

Keywords

  • Cardiovascular function
  • Hypoxemia
  • Sheep model

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of Hypoxemia with or without Increased Placental Vascular Resistance on Fetal Left and Right Ventricular Myocardial Performance Index in Chronically Instrumented Sheep. / Bhide, Amar; Vuolteenaho, Olli; Haapsamo, Mervi; Erkinaro, Tiina; Rasanen, Juha; Acharya, Ganesh.

In: Ultrasound in Medicine and Biology, Vol. 42, No. 11, 01.11.2016, p. 2589-2598.

Research output: Contribution to journalArticle

Bhide, Amar ; Vuolteenaho, Olli ; Haapsamo, Mervi ; Erkinaro, Tiina ; Rasanen, Juha ; Acharya, Ganesh. / Effect of Hypoxemia with or without Increased Placental Vascular Resistance on Fetal Left and Right Ventricular Myocardial Performance Index in Chronically Instrumented Sheep. In: Ultrasound in Medicine and Biology. 2016 ; Vol. 42, No. 11. pp. 2589-2598.
@article{5748526f546b4c5ba8ff1f6c58436938,
title = "Effect of Hypoxemia with or without Increased Placental Vascular Resistance on Fetal Left and Right Ventricular Myocardial Performance Index in Chronically Instrumented Sheep",
abstract = "Myocardial performance index (MPI) is increased in growth-restricted fetuses with placental insufficiency, but it is unknown if this is due to fetal hypoxemia or increased placental vascular resistance (Rplac). We used chronically instrumented sheep fetuses (n = 24). In 12 fetuses, placental embolization was performed 24 h before experiments. On the day of the experiment, left (LV) and right (RV) ventricular MPIs were obtained by pulsed Doppler at baseline and in the hypoxemia and recovery phases. At baseline, Rplac was greater and fetal pO2 lower in the placental embolization group, but RV and LV MPIs were comparable to those of the control group. During hypoxemia, mean LV MPI increased significantly only in fetuses with an intact placenta (0.34 vs. 0.46), returning to baseline during the recovery phase. Right ventricular MPI was unaffected. We conclude that fetal LV function is sensitive to acute hypoxemia. Exposure to chronic hypoxemia could pre-condition the fetal heart and protect its function with worsening hypoxemia.",
keywords = "Cardiovascular function, Hypoxemia, Sheep model",
author = "Amar Bhide and Olli Vuolteenaho and Mervi Haapsamo and Tiina Erkinaro and Juha Rasanen and Ganesh Acharya",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.ultrasmedbio.2016.07.006",
language = "English (US)",
volume = "42",
pages = "2589--2598",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Effect of Hypoxemia with or without Increased Placental Vascular Resistance on Fetal Left and Right Ventricular Myocardial Performance Index in Chronically Instrumented Sheep

AU - Bhide, Amar

AU - Vuolteenaho, Olli

AU - Haapsamo, Mervi

AU - Erkinaro, Tiina

AU - Rasanen, Juha

AU - Acharya, Ganesh

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Myocardial performance index (MPI) is increased in growth-restricted fetuses with placental insufficiency, but it is unknown if this is due to fetal hypoxemia or increased placental vascular resistance (Rplac). We used chronically instrumented sheep fetuses (n = 24). In 12 fetuses, placental embolization was performed 24 h before experiments. On the day of the experiment, left (LV) and right (RV) ventricular MPIs were obtained by pulsed Doppler at baseline and in the hypoxemia and recovery phases. At baseline, Rplac was greater and fetal pO2 lower in the placental embolization group, but RV and LV MPIs were comparable to those of the control group. During hypoxemia, mean LV MPI increased significantly only in fetuses with an intact placenta (0.34 vs. 0.46), returning to baseline during the recovery phase. Right ventricular MPI was unaffected. We conclude that fetal LV function is sensitive to acute hypoxemia. Exposure to chronic hypoxemia could pre-condition the fetal heart and protect its function with worsening hypoxemia.

AB - Myocardial performance index (MPI) is increased in growth-restricted fetuses with placental insufficiency, but it is unknown if this is due to fetal hypoxemia or increased placental vascular resistance (Rplac). We used chronically instrumented sheep fetuses (n = 24). In 12 fetuses, placental embolization was performed 24 h before experiments. On the day of the experiment, left (LV) and right (RV) ventricular MPIs were obtained by pulsed Doppler at baseline and in the hypoxemia and recovery phases. At baseline, Rplac was greater and fetal pO2 lower in the placental embolization group, but RV and LV MPIs were comparable to those of the control group. During hypoxemia, mean LV MPI increased significantly only in fetuses with an intact placenta (0.34 vs. 0.46), returning to baseline during the recovery phase. Right ventricular MPI was unaffected. We conclude that fetal LV function is sensitive to acute hypoxemia. Exposure to chronic hypoxemia could pre-condition the fetal heart and protect its function with worsening hypoxemia.

KW - Cardiovascular function

KW - Hypoxemia

KW - Sheep model

UR - http://www.scopus.com/inward/record.url?scp=84990967235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990967235&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2016.07.006

DO - 10.1016/j.ultrasmedbio.2016.07.006

M3 - Article

C2 - 27544438

AN - SCOPUS:84990967235

VL - 42

SP - 2589

EP - 2598

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 11

ER -