Effect of Hypoxemia on Fetal Ventricular Deformation in a Chronically Instrumented Sheep Model

Amarnath Bhide, Juha Rasanen, Heikki Huhta, Juulia Junno, Tiina Erkinaro, Pasi Ohtonen, Mervi Haapsamo, Ganesh Acharya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We hypothesized that in near-term sheep fetuses, hypoxemia changes myocardial function as reflected in altered ventricular deformation on speckle-tracking echocardiography. Fetuses in 21 pregnant sheep were instrumented. After 4 d of recovery, fetal cardiac function was assessed by echocardiography at baseline, after 30 and 120 min of induced fetal hypoxemia and after its reversal. Left (LV) and right (RV) ventricular cardiac output and myocardial strain were measured. Baseline mean (standard deviation [SD]) LV and RV global longitudinal strains were −18.7% (3.8) and −14.3% (5.3). Baseline RV global longitudinal and circumferential deformations were less compared with those of the left ventricle (p = 0.016 and p < 0.005). LV, but not RV, global longitudinal strain was decreased (p = 0.003) compared with baseline with hypoxemia. Circumferential and radial strains did not exhibit significant changes. In the near-term sheep fetus, LV global longitudinal and circumferential strains are more negative than RV strains. Acute hypoxemia leads to LV rather than RV dysfunction as reflected by decreased deformation.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalUltrasound in Medicine and Biology
Volume43
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

hypoxemia
sheep
Sheep
fetuses
echocardiography
Fetus
Echocardiography
cardiac output
Cardiac Output
Heart Ventricles
standard deviation
recovery
Hypoxia

Keywords

  • Hypoxemia
  • Sheep model
  • Speckle-tracking echocardiography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of Hypoxemia on Fetal Ventricular Deformation in a Chronically Instrumented Sheep Model. / Bhide, Amarnath; Rasanen, Juha; Huhta, Heikki; Junno, Juulia; Erkinaro, Tiina; Ohtonen, Pasi; Haapsamo, Mervi; Acharya, Ganesh.

In: Ultrasound in Medicine and Biology, Vol. 43, No. 5, 01.05.2017, p. 967-973.

Research output: Contribution to journalArticle

Bhide, A, Rasanen, J, Huhta, H, Junno, J, Erkinaro, T, Ohtonen, P, Haapsamo, M & Acharya, G 2017, 'Effect of Hypoxemia on Fetal Ventricular Deformation in a Chronically Instrumented Sheep Model', Ultrasound in Medicine and Biology, vol. 43, no. 5, pp. 967-973. https://doi.org/10.1016/j.ultrasmedbio.2017.01.010
Bhide, Amarnath ; Rasanen, Juha ; Huhta, Heikki ; Junno, Juulia ; Erkinaro, Tiina ; Ohtonen, Pasi ; Haapsamo, Mervi ; Acharya, Ganesh. / Effect of Hypoxemia on Fetal Ventricular Deformation in a Chronically Instrumented Sheep Model. In: Ultrasound in Medicine and Biology. 2017 ; Vol. 43, No. 5. pp. 967-973.
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