Effect of hyperoxemia and ritanserin on skeletal muscle microflow

Per Thorborg, U. Gustafsson, F. Sjoberg, D. K. Harrison, D. H. Lewis

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Serotonin2 (5-HT2) receptor antagonists (ketanserin, ritanserin) can normalize a hyperoxemia-induced disturbance in skeletal muscle oxygenation, presumably by local microflow changes. The purpose of this study was to develop equipment for local hydrogen clearance measurements with a modified eight-channel platinum electrode to assess changes in local skeletal muscle capillary blood flow induced by hyperoxemia and ritanserin (0.035 mg/kg) during hyperoxemia. Laser-Doppler flowmetry was used for regional microflow measurements. Two groups of six anesthetized and artifically ventilated rabbits were studied: group I with normoxemia and hyperoxemia [arterial PO2 (Pa(O2)) 48 kPa; 360 Torr] and group II before and after ritanserin with hyperoxemia (Pa(O2) 46 kPa; 345 Torr). In group I, hyperoxemia induced a mean local hydrogen clearance decrease of 22% while laser-Doppler flowmetry signal decreased 31%. In group II, ritanserin induced a 125% mean local hydrogen clearance increase compared with hyperoxemia (or 37% compared with group I normoxemia); laser-Doppler flowmetry signal increased 30%. The sum distribution of local hydrogen clearances shifted to the left during hyperoxemia and to the right after ritanserin. The conclusion from this study is that local and regional microflow changes can explain the effects of hyperoxemia and ritanserin on skeletal muscle oxygenation.

Original languageEnglish (US)
Pages (from-to)1494-1500
Number of pages7
JournalJournal of Applied Physiology
Volume68
Issue number4
StatePublished - 1990
Externally publishedYes

Fingerprint

Ritanserin
Skeletal Muscle
Laser-Doppler Flowmetry
Hydrogen
Serotonin 5-HT2 Receptor Antagonists
Ketanserin
Platinum
Electrodes
Rabbits
Equipment and Supplies

Keywords

  • laser-Doppler flowmetry
  • local hydrogen clearance
  • microcirculation
  • regulation of skeletal muscle oxygenation
  • serotonin receptor antagonist

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Thorborg, P., Gustafsson, U., Sjoberg, F., Harrison, D. K., & Lewis, D. H. (1990). Effect of hyperoxemia and ritanserin on skeletal muscle microflow. Journal of Applied Physiology, 68(4), 1494-1500.

Effect of hyperoxemia and ritanserin on skeletal muscle microflow. / Thorborg, Per; Gustafsson, U.; Sjoberg, F.; Harrison, D. K.; Lewis, D. H.

In: Journal of Applied Physiology, Vol. 68, No. 4, 1990, p. 1494-1500.

Research output: Contribution to journalArticle

Thorborg, P, Gustafsson, U, Sjoberg, F, Harrison, DK & Lewis, DH 1990, 'Effect of hyperoxemia and ritanserin on skeletal muscle microflow', Journal of Applied Physiology, vol. 68, no. 4, pp. 1494-1500.
Thorborg P, Gustafsson U, Sjoberg F, Harrison DK, Lewis DH. Effect of hyperoxemia and ritanserin on skeletal muscle microflow. Journal of Applied Physiology. 1990;68(4):1494-1500.
Thorborg, Per ; Gustafsson, U. ; Sjoberg, F. ; Harrison, D. K. ; Lewis, D. H. / Effect of hyperoxemia and ritanserin on skeletal muscle microflow. In: Journal of Applied Physiology. 1990 ; Vol. 68, No. 4. pp. 1494-1500.
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