Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma

Claudio Anasetti, Patrick G. Beatty, Rainer Storb, Paul J. Martin, Motomi (Tomi) Mori, Jean E. Sanders, E. Donnall Thomas, John A. Hansen

Research output: Contribution to journalArticle

267 Citations (Scopus)

Abstract

We analyzed the relevance of HLA incompatibility to acute graft-versus-host disease, relapse, and survival in 281 patients with hematologic neoplasms who underwent bone marrow transplantation. Each patient received marrow from a family member who shared one HLA haplotype with the patient but differed to a variable degree for the HLA-A,-B, and -D antigens of the haplotype not shared: 29 were phenotypically identical, 119 were incompatible for one locus, 104 for two loci, and 29 for three loci. These 281 patients were compared with 967 patients who received marrow from siblings with identical HLA genotypes. All patients were treated with cyclophosphamide and total-body irradiation followed by the infusion of unmodified donor marrow cells. Occurence of severe acute graft-versus-host disease was evaluated in patients who achieved sustained engraftment. In recipients of haploidentical grafts of severe acute graft-versus-host disease was associated with (1) graft-versus-host disease prophylaxis containing the combination of methotrexate plus cyclosporine versus standard methotrexate, relative risk = 0.35; 95% confidence interval, 0.21-0.57, p

Original languageEnglish (US)
Pages (from-to)79-91
Number of pages13
JournalHuman Immunology
Volume29
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Graft vs Host Disease
Lymphoma
Leukemia
Transplantation
Bone Marrow
Recurrence
Survival
Methotrexate
Haplotypes
HLA-A Antigens
HLA-B Antigens
Whole-Body Irradiation
Hematologic Neoplasms
Bone Marrow Transplantation
Cyclophosphamide
Cyclosporine
Siblings
Genotype
Tissue Donors
Confidence Intervals

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. / Anasetti, Claudio; Beatty, Patrick G.; Storb, Rainer; Martin, Paul J.; Mori, Motomi (Tomi); Sanders, Jean E.; Donnall Thomas, E.; Hansen, John A.

In: Human Immunology, Vol. 29, No. 2, 1990, p. 79-91.

Research output: Contribution to journalArticle

Anasetti, Claudio ; Beatty, Patrick G. ; Storb, Rainer ; Martin, Paul J. ; Mori, Motomi (Tomi) ; Sanders, Jean E. ; Donnall Thomas, E. ; Hansen, John A. / Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. In: Human Immunology. 1990 ; Vol. 29, No. 2. pp. 79-91.
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