Effect of glycemic state on hospital mortality in critically ill surgical patients

Albert Chi, Matthew E. Lissauer, Jill Kirchoffner, Thomas M. Scalea, Steven B. Johnson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Intensive insulin therapy can reduce mortality. Hypoglycemia related to intensive therapy may worsen outcomes. This study compared risk adjusted mortality for different glycemic states. A retrospective review of patients admitted to a surgical intensive care unit over 4 years was performed. Patients were divided into glycemic groups: HYPER (≥1 episode >180 mg/dL, any <60), HYPO (≥1 episode <60 mg/dL, any >180), BOTH (≥1 episode <60 and ≥1 episode>180 mg/dL), NORMO (all episodes 60-180 mg/dL), HYPER-Only (≥1 episode > 180, none <60 mg/dL), and HYPO-Only (≥1 episode <60, none >180 mg/dL). Observed to expected Acute Physiology and Chronic Health Evaluation (APACHE) III mortality ratios (O/E) were studied. Number of adverse glycemic events was compared with mortality. Hypoglycemia and hyperglycemia occurred in 18 per cent and 50 per cent of patients. Mortality was 12.4 per cent (O/E = 0.88). BOTH had the highest O/E ratio (1.43) with HYPO the second highest (1.30). Groups excluding hypoglycemia (NORMO and HYPER-only) had the lowest O/E ratios: 0.56 and 0.88. Increasing number of hypoglycemic events were associated with increasing O/E ratio: 0.69 O/E for no events, 1.19 for 1-3 events, 1.35 for 4-6 events, 1.9 for 7-9 events, and 3.13 for ≥ 10 events. Ten or more hyperglycemic events were needed to significantly associate with worse mortality (O/E 1.53). Hyper- and hypoglycemia increase mortality compared with APACHE III expected mortality, with highest mortality risk if both are present. Hypoglycemia is associated with worse risk. Glucose control may need to be loosened to prevent hypoglycemia and reduce glucose variability.

Original languageEnglish (US)
Pages (from-to)1483-1489
Number of pages7
JournalAmerican Surgeon
Volume77
Issue number11
StatePublished - Nov 1 2011
Externally publishedYes

Fingerprint

State Hospitals
Hospital Mortality
Critical Illness
Hypoglycemia
Mortality
APACHE
Hyperglycemia
Glucose
Critical Care
Hypoglycemic Agents
Intensive Care Units
Insulin

ASJC Scopus subject areas

  • Surgery

Cite this

Chi, A., Lissauer, M. E., Kirchoffner, J., Scalea, T. M., & Johnson, S. B. (2011). Effect of glycemic state on hospital mortality in critically ill surgical patients. American Surgeon, 77(11), 1483-1489.

Effect of glycemic state on hospital mortality in critically ill surgical patients. / Chi, Albert; Lissauer, Matthew E.; Kirchoffner, Jill; Scalea, Thomas M.; Johnson, Steven B.

In: American Surgeon, Vol. 77, No. 11, 01.11.2011, p. 1483-1489.

Research output: Contribution to journalArticle

Chi, A, Lissauer, ME, Kirchoffner, J, Scalea, TM & Johnson, SB 2011, 'Effect of glycemic state on hospital mortality in critically ill surgical patients', American Surgeon, vol. 77, no. 11, pp. 1483-1489.
Chi A, Lissauer ME, Kirchoffner J, Scalea TM, Johnson SB. Effect of glycemic state on hospital mortality in critically ill surgical patients. American Surgeon. 2011 Nov 1;77(11):1483-1489.
Chi, Albert ; Lissauer, Matthew E. ; Kirchoffner, Jill ; Scalea, Thomas M. ; Johnson, Steven B. / Effect of glycemic state on hospital mortality in critically ill surgical patients. In: American Surgeon. 2011 ; Vol. 77, No. 11. pp. 1483-1489.
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