Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs

Robert Hitzemann, Kristin Demarest, Jay Koyner, Laura Cipp, Nilay Patel, Eric Rasmussen, James McCaughran

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A genome-wide scan was conducted in two F2 intercrosses, C57BL/6J (B6) × DBA/2J (D2) and BALB/cJ (C) × LP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD ≥ 4.3) were detected on chromosomes 9 and 19 for the C × LP intercross and chromosome 1 for the B6 × D2 intercross. Significant QTLs for ethanol-induced activation were detected on chromosome 6 for the C × LP intercross, and on chromosomes 1 and 2 for the B6 × D2 intercross. For haloperidol-induced catalepsy, significant QTLs were detected on chromosome 14 (two different QTLs) in the C × LP intercross, and chromosomes 1 and 9 in the B6 × D2 intercross. These data illustrate the importance of the genetic cross for QTL detection. Finally, the data reported here, and elsewhere, are also used to demonstrate a novel approach to QTL detection and localization.

Original languageEnglish (US)
Pages (from-to)767-772
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume67
Issue number4
DOIs
StatePublished - Dec 1 2000

Keywords

  • Catalepsy
  • Ethanol
  • Haloperidol
  • Locomotor activity
  • Mouse
  • Quantitative trait loci

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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