Effect of gamma-vinyl GABA in tardive dyskinesia

Søren Korsgaard; Daniel E. Casey; Jes Gerlach

doi:10.1016/0165-1781(83)90014-8

Effect of gamma-vinyl GABA in tardive dyskinesia

Søren Korsgaard, Daniel E. Casey, Jes Gerlach

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

γ-Vinyl GABA (γ-aminobutyric acid), a drug that increases brain GABA via GABA transaminase inhibition, was evaluated in a blind, placebo-controlled trial in 10 patients with stable tardive dyskinesia. Drug effects during active treatment (2 to 6 g/day) and during pre- and posttreatment placebo periods were determined by scoring randomly sequenced videotapes of tardive dyskinesia and parkisonian symptoms recorded weekly during standardized examinations. Tardive dyskinesia was significantly reduced, and correlated to increased parkinsonism. Eye blinking rates decreased, but psychiatric symptoms were unchanged during treatment.

Original language	English (US)
Pages (from-to)	261-269
Number of pages	9
Journal	Psychiatry Research
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0165-1781(83)90014-8
State	Published - Apr 1983
Externally published	Yes

Keywords

parkinsonism
tardive dyskinesia
γ-Vinyl GABA

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(83)90014-8

Cite this

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title = "Effect of gamma-vinyl GABA in tardive dyskinesia",

abstract = "γ-Vinyl GABA (γ-aminobutyric acid), a drug that increases brain GABA via GABA transaminase inhibition, was evaluated in a blind, placebo-controlled trial in 10 patients with stable tardive dyskinesia. Drug effects during active treatment (2 to 6 g/day) and during pre- and posttreatment placebo periods were determined by scoring randomly sequenced videotapes of tardive dyskinesia and parkisonian symptoms recorded weekly during standardized examinations. Tardive dyskinesia was significantly reduced, and correlated to increased parkinsonism. Eye blinking rates decreased, but psychiatric symptoms were unchanged during treatment.",

keywords = "parkinsonism, tardive dyskinesia, γ-Vinyl GABA",

author = "S{\o}ren Korsgaard and Casey, {Daniel E.} and Jes Gerlach",

note = "Funding Information: Acknowledgments. This study was supported by the Danish Foundation for the Advancement of Medical Science (video equipment). Centre de Recherche Merrell International, Strasbourg. France, supplied the GVG. Tilli Wanstrup provided technical assistance.",

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AU - Korsgaard, Søren

AU - Casey, Daniel E.

AU - Gerlach, Jes

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N2 - γ-Vinyl GABA (γ-aminobutyric acid), a drug that increases brain GABA via GABA transaminase inhibition, was evaluated in a blind, placebo-controlled trial in 10 patients with stable tardive dyskinesia. Drug effects during active treatment (2 to 6 g/day) and during pre- and posttreatment placebo periods were determined by scoring randomly sequenced videotapes of tardive dyskinesia and parkisonian symptoms recorded weekly during standardized examinations. Tardive dyskinesia was significantly reduced, and correlated to increased parkinsonism. Eye blinking rates decreased, but psychiatric symptoms were unchanged during treatment.

AB - γ-Vinyl GABA (γ-aminobutyric acid), a drug that increases brain GABA via GABA transaminase inhibition, was evaluated in a blind, placebo-controlled trial in 10 patients with stable tardive dyskinesia. Drug effects during active treatment (2 to 6 g/day) and during pre- and posttreatment placebo periods were determined by scoring randomly sequenced videotapes of tardive dyskinesia and parkisonian symptoms recorded weekly during standardized examinations. Tardive dyskinesia was significantly reduced, and correlated to increased parkinsonism. Eye blinking rates decreased, but psychiatric symptoms were unchanged during treatment.

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Effect of gamma-vinyl GABA in tardive dyskinesia

Abstract

Keywords

ASJC Scopus subject areas

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