Effect of extracorporeal membrane oxygenation on left ventricular function of swine

Irving Shen, Fiona H. Levy, Craig R. Vocelka, P. Pearl O'Rourke, Brian W. Duncan, Robert Thomas, Edward D. Verrier

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background. Previous clinical and experimental investigations have produced inconsistent data describing the effects of veno-arterial extracorporeal membrane oxygenation (VA ECMO) on intrinsic left ventricular (LV) function. We report an animal model that allows investigation of the effects of VA ECMO on the mechanics of the LV using two load-insensitive indices: end-systolic pressure-minor axis dimension relationship (ESPDR) and preload recruitable dimensional stroke work (PRDSW). Methods. Eight piglets (5 to 11 kg) were anesthetized, instrumented, and placed on VA ECMO. Throughout the experiment, systemic and left atrial partial pressure of oxygen were maintained between 100 to 200 mm Hg. At ECMO flow rate of 50% of baseline cardiac output, data were collected prior to ECMO, at 4 and 6 hours during ECMO, and after weaning from ECMO. Data measured or calculated for each time point included heart rate, LV pressures and minor axis dimensions at different preloads, first derivative of LV pressure with respect to time, velocity of circumferential fiber length shortening (VCF), LV shortening fraction (LVSF), ESPDR, and PRDSW. Results. A significant (p <0.05) decrease in LVSF and VCF was seen at 4 and 6 hours during ECMO when compared to baseline, but the ESPDR and PRDSW did not change during ECMO. Conclusions. VA ECMO alone changes some of the load-dependent parameters of contractility, but intrinsic function of the heart is not significantly affected as measured by load-insensitive indices of LV performance.

Original languageEnglish (US)
Pages (from-to)862-867
Number of pages6
JournalAnnals of Thoracic Surgery
Volume71
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Extracorporeal Membrane Oxygenation
Left Ventricular Function
Swine
Stroke
Ventricular Pressure
Blood Pressure
Atrial Pressure
Partial Pressure
Weaning
Mechanics
Cardiac Output
Animal Models
Heart Rate
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Shen, I., Levy, F. H., Vocelka, C. R., O'Rourke, P. P., Duncan, B. W., Thomas, R., & Verrier, E. D. (2001). Effect of extracorporeal membrane oxygenation on left ventricular function of swine. Annals of Thoracic Surgery, 71(3), 862-867. https://doi.org/10.1016/S0003-4975(00)02280-3

Effect of extracorporeal membrane oxygenation on left ventricular function of swine. / Shen, Irving; Levy, Fiona H.; Vocelka, Craig R.; O'Rourke, P. Pearl; Duncan, Brian W.; Thomas, Robert; Verrier, Edward D.

In: Annals of Thoracic Surgery, Vol. 71, No. 3, 2001, p. 862-867.

Research output: Contribution to journalArticle

Shen, I, Levy, FH, Vocelka, CR, O'Rourke, PP, Duncan, BW, Thomas, R & Verrier, ED 2001, 'Effect of extracorporeal membrane oxygenation on left ventricular function of swine', Annals of Thoracic Surgery, vol. 71, no. 3, pp. 862-867. https://doi.org/10.1016/S0003-4975(00)02280-3
Shen, Irving ; Levy, Fiona H. ; Vocelka, Craig R. ; O'Rourke, P. Pearl ; Duncan, Brian W. ; Thomas, Robert ; Verrier, Edward D. / Effect of extracorporeal membrane oxygenation on left ventricular function of swine. In: Annals of Thoracic Surgery. 2001 ; Vol. 71, No. 3. pp. 862-867.
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AU - Thomas, Robert

AU - Verrier, Edward D.

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N2 - Background. Previous clinical and experimental investigations have produced inconsistent data describing the effects of veno-arterial extracorporeal membrane oxygenation (VA ECMO) on intrinsic left ventricular (LV) function. We report an animal model that allows investigation of the effects of VA ECMO on the mechanics of the LV using two load-insensitive indices: end-systolic pressure-minor axis dimension relationship (ESPDR) and preload recruitable dimensional stroke work (PRDSW). Methods. Eight piglets (5 to 11 kg) were anesthetized, instrumented, and placed on VA ECMO. Throughout the experiment, systemic and left atrial partial pressure of oxygen were maintained between 100 to 200 mm Hg. At ECMO flow rate of 50% of baseline cardiac output, data were collected prior to ECMO, at 4 and 6 hours during ECMO, and after weaning from ECMO. Data measured or calculated for each time point included heart rate, LV pressures and minor axis dimensions at different preloads, first derivative of LV pressure with respect to time, velocity of circumferential fiber length shortening (VCF), LV shortening fraction (LVSF), ESPDR, and PRDSW. Results. A significant (p <0.05) decrease in LVSF and VCF was seen at 4 and 6 hours during ECMO when compared to baseline, but the ESPDR and PRDSW did not change during ECMO. Conclusions. VA ECMO alone changes some of the load-dependent parameters of contractility, but intrinsic function of the heart is not significantly affected as measured by load-insensitive indices of LV performance.

AB - Background. Previous clinical and experimental investigations have produced inconsistent data describing the effects of veno-arterial extracorporeal membrane oxygenation (VA ECMO) on intrinsic left ventricular (LV) function. We report an animal model that allows investigation of the effects of VA ECMO on the mechanics of the LV using two load-insensitive indices: end-systolic pressure-minor axis dimension relationship (ESPDR) and preload recruitable dimensional stroke work (PRDSW). Methods. Eight piglets (5 to 11 kg) were anesthetized, instrumented, and placed on VA ECMO. Throughout the experiment, systemic and left atrial partial pressure of oxygen were maintained between 100 to 200 mm Hg. At ECMO flow rate of 50% of baseline cardiac output, data were collected prior to ECMO, at 4 and 6 hours during ECMO, and after weaning from ECMO. Data measured or calculated for each time point included heart rate, LV pressures and minor axis dimensions at different preloads, first derivative of LV pressure with respect to time, velocity of circumferential fiber length shortening (VCF), LV shortening fraction (LVSF), ESPDR, and PRDSW. Results. A significant (p <0.05) decrease in LVSF and VCF was seen at 4 and 6 hours during ECMO when compared to baseline, but the ESPDR and PRDSW did not change during ECMO. Conclusions. VA ECMO alone changes some of the load-dependent parameters of contractility, but intrinsic function of the heart is not significantly affected as measured by load-insensitive indices of LV performance.

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