Abstract
Ether tethers allow Heck cyclizations to proceed in high yields. Ester tethers lead to low yields. Styrene trapping experiments indicate that ester reactions form viable organopalladium intermediates that cannot cyclize efficiently.
Original language | English (US) |
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Pages (from-to) | 7213-7215 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 42 |
DOIs | |
State | Published - Oct 17 2005 |
Externally published | Yes |
Keywords
- Ester rotation barrier
- Heck cyclization
- Tethered cyclization
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry