Effect of Donor Recipient Age Match on Survival after First Deceased Donor Renal Transplantation

Douglas S. Keith, Angelo Demattos, Muralikrishna Golconda, Jonathan Prather, Douglas Norman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Donor-recipient age matching has been proposed as a means of improving overall outcomes in deceased donor renal transplantation. It was hypothesized that donor-recipient age matching would improve patient survival time in younger recipients while not adversely affecting patient survivals in older recipients because they seldom outlive their grafts. By use of data from United Network of Organ Sharing Standard Transplant and Analysis and Research Files 50,320 patients were identified who underwent a first deceased donor renal transplantation between January 1, 1990, and December 31, 1997. Adjusted patient survival and death-with-graft function patient survival were analyzed from the date of transplantation. Patient survival was affected by donor age for all recipient age groups, including recipients older than 55 yr. The effect of donor age on patient survival is greater than that seen with HLA matching. The effect of donor age on patient survival persisted even when censoring recipients in whom grafts failed before death, suggesting that both longevity and quality of graft function are important in patient survival. Donor-recipient age matching is occurring to a limited degree in this population. Donor-recipient age matching would improve survival in younger recipients but would adversely affect survival in older patients by reducing the availability of younger donor kidneys for this group. The issue of donor-recipient age matching needs to be debated among the public and transplantation community so that a logical and just system can be developed.

Original languageEnglish (US)
Pages (from-to)1086-1091
Number of pages6
JournalJournal of the American Society of Nephrology
Volume15
Issue number4
DOIs
StatePublished - Apr 2004

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Kidney Transplantation
Tissue Donors
Survival
Transplants
Transplantation
Age Groups
Kidney

ASJC Scopus subject areas

  • Nephrology

Cite this

Effect of Donor Recipient Age Match on Survival after First Deceased Donor Renal Transplantation. / Keith, Douglas S.; Demattos, Angelo; Golconda, Muralikrishna; Prather, Jonathan; Norman, Douglas.

In: Journal of the American Society of Nephrology, Vol. 15, No. 4, 04.2004, p. 1086-1091.

Research output: Contribution to journalArticle

Keith, Douglas S. ; Demattos, Angelo ; Golconda, Muralikrishna ; Prather, Jonathan ; Norman, Douglas. / Effect of Donor Recipient Age Match on Survival after First Deceased Donor Renal Transplantation. In: Journal of the American Society of Nephrology. 2004 ; Vol. 15, No. 4. pp. 1086-1091.
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