Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion

Cuneyt Temiz, Aclan Dogan, Mustafa K. Baskaya, Robert J. Dempsey

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Polyamines have been shown to play an important role in the disturbance of the blood-brain barrier (BBB) in a number of pathological states including ischemia. BBB disturbances may be almost completely prevented by treating animals with the ornithine decarboxylase (ODC) inhibitor, α- difluoromethylornithine (DFMO). DFMO has been also shown to prevent N-Methyl-d-aspartate (NMDA) toxicity in tissue cultures. It has been suggested that the pathological disturbances in polyamine metabolism observed following cerebral ischemia, particularly the post-ischemic increase in putrescine, may contribute to the ischemic injury that is most evident in the CA1 subfield of the hippocampus. In this study, effects of DFMO in cerebral ischemia and reperfusion were examined. The results showed that inhibition of the polyamine system by DFMO decreased ischemic injury volume and brain tissue water content in a dose-dependent manner, without change in vital signs, including systemic arterial blood pressure, arterial partial oxygen pressure, regional cerebral blood flow and body temperature.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalJournal of Clinical Neuroscience
Volume12
Issue number4
DOIs
StatePublished - May 1 2005

Keywords

  • Cerebral ischemia
  • Polyamines
  • Reperfusion
  • α-difluoromethylornithine

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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