Abstract
To determine whether increasing dietary protein could exert a beneficial effect on bed-rest-related protein catabolism, two groups of normal subjects were subjected to 7 d of bed rest while taking isocaloric diets containing either 0.6 or 1.0 g protein·kg body wt-1·d-1. Whole-body-leucine turnover, leucine oxidation, and nonoxidative leucine disappearance were measured by use of a constant infusion of 1-13C-leucine. Before bed rest, the higher-protein diet resulted in a 14% decrease in whole-body-leucine turnover and a 28% decrease in leucine oxidation, but net nonoxidative leucine disappearance was not different on the two diets. A 24% decrease in nonoxidative leucine disappearance was seen in subjects assigned to the lower-protein diet, who had been on bed rest, but on the higher-protein diet, leucine kinetics were unchanged by bed rest. Bed rest does not cause an increase in whole-body-protein breakdown, but decreased whole-body-protein synthesis is demonstrable when dietary protein is low. This decrease is prevented by a higher dietary amount of protein.
Original language | English (US) |
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Pages (from-to) | 509-514 |
Number of pages | 6 |
Journal | American Journal of Clinical Nutrition |
Volume | 52 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1990 |
Externally published | Yes |
Keywords
- Bed rest
- Dietary protein
- Insulin
- Leucine kinetics
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics