Effect of dietary macronutrient content on carnitine excretion and efficiency of carnitine reabsorption

Diane Stadler, Catherine A. Chenard, Charles J. Rebouche

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined the effect of macronutrient content on glomerular filtration rate (GFR), and excretion, reabsorption, and filtered load of carnitine. Ten subjects consumed five diets [high protein (HP), low protein (LP), control, high fat (HF), and high carbohydrate (HC)] of equal energy and carnitine content for 6 d each, in a randomized crossover manner. The rate of carnitine excretion was lower after the LP diet than after the HP diet because of lower GFR after the LP diet. The rate of carnitine reabsorption was lower after the LP diet than after the HP diet, also because of the lower GFR after the LP diet. The rate of carnitine reabsorption was not different after the HF and HC diets, nor was GFR. The filtered load of carnitine, however, was greater after the HF diet, resulting in a higher rate of carnitine excretion.

Original languageEnglish (US)
Pages (from-to)868-872
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume58
Issue number6
StatePublished - Dec 1993
Externally publishedYes

Fingerprint

Carnitine
carnitine
Protein-Restricted Diet
excretion
glomerular filtration rate
low protein diet
Glomerular Filtration Rate
high protein diet
High Fat Diet
Carbohydrates
Diet
high carbohydrate diet
Proteins
high fat diet
lipids
Fats
carbohydrates
energy

Keywords

  • Carnitine reabsorption
  • Diet
  • Glomerular filtration rate
  • Macronutrient composition
  • Urinary carnitine excretion

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of dietary macronutrient content on carnitine excretion and efficiency of carnitine reabsorption. / Stadler, Diane; Chenard, Catherine A.; Rebouche, Charles J.

In: American Journal of Clinical Nutrition, Vol. 58, No. 6, 12.1993, p. 868-872.

Research output: Contribution to journalArticle

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