Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration

Wei Wang, Sonja L. Connor, Elizabeth J. Johnson, Michael Klein, Shannon Hughes, William E. Connor

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Background: Lowdietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. Objective: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. Design: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (≈1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (≈11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. Results: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; ≈22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of α-carotene, β-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. Conclusions: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.

Original languageEnglish (US)
Pages (from-to)762-769
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume85
Issue number3
StatePublished - Mar 1 2007
Externally publishedYes

Fingerprint

Lutein
Macular Degeneration
zeaxanthin
Carotenoids
lutein
lipoproteins
Lipoproteins
carotenoids
Diet
diet
carotenes
lycopene
Zeaxanthins
macular degeneration
retina
Retina

Keywords

  • Age
  • HDL cholesterol
  • LDL cholesterol
  • Macular degeneration
  • Retina
  • VLDL cholesterol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. / Wang, Wei; Connor, Sonja L.; Johnson, Elizabeth J.; Klein, Michael; Hughes, Shannon; Connor, William E.

In: American Journal of Clinical Nutrition, Vol. 85, No. 3, 01.03.2007, p. 762-769.

Research output: Contribution to journalArticle

Wang, Wei ; Connor, Sonja L. ; Johnson, Elizabeth J. ; Klein, Michael ; Hughes, Shannon ; Connor, William E. / Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. In: American Journal of Clinical Nutrition. 2007 ; Vol. 85, No. 3. pp. 762-769.
@article{c010d0b06ae6438bb4ee13c921be4b38,
title = "Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration",
abstract = "Background: Lowdietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. Objective: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. Design: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (≈1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (≈11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. Results: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52{\%} of the lutein and 44{\%} of the zeaxanthin were transported by HDL; ≈22{\%} of lutein and zeaxanthin was transported by LDL. Only 20-25{\%} of α-carotene, β-carotene, and lycopene was transported by HDL; 50-57{\%} was transported by LDL. Conclusions: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.",
keywords = "Age, HDL cholesterol, LDL cholesterol, Macular degeneration, Retina, VLDL cholesterol",
author = "Wei Wang and Connor, {Sonja L.} and Johnson, {Elizabeth J.} and Michael Klein and Shannon Hughes and Connor, {William E.}",
year = "2007",
month = "3",
day = "1",
language = "English (US)",
volume = "85",
pages = "762--769",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration

AU - Wang, Wei

AU - Connor, Sonja L.

AU - Johnson, Elizabeth J.

AU - Klein, Michael

AU - Hughes, Shannon

AU - Connor, William E.

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Background: Lowdietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. Objective: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. Design: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (≈1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (≈11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. Results: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; ≈22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of α-carotene, β-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. Conclusions: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.

AB - Background: Lowdietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. Objective: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. Design: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (≈1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (≈11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. Results: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; ≈22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of α-carotene, β-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. Conclusions: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.

KW - Age

KW - HDL cholesterol

KW - LDL cholesterol

KW - Macular degeneration

KW - Retina

KW - VLDL cholesterol

UR - http://www.scopus.com/inward/record.url?scp=33847781431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847781431&partnerID=8YFLogxK

M3 - Article

C2 - 17344498

AN - SCOPUS:33847781431

VL - 85

SP - 762

EP - 769

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -