Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine

Robert Hitzemann, Horace H. Loh

Research output: Contribution to journalArticle

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Abstract

The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.

Original languageEnglish (US)
Pages (from-to)2731-2741
Number of pages11
JournalBiochemical Pharmacology
Volume22
Issue number21
DOIs
Publication statusPublished - Nov 1 1973
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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