TY - JOUR
T1 - Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine
AU - Hitzemann, Robert J.
AU - Loh, Horace H.
N1 - Funding Information:
*This study was supported in part by United States Public Health Service Grant MH-24036 and Army Contract DADA 17-73-C-3127. Dr. H. H. Loh is a recipient of a National Institute of Mental Health Research Scientist Development Award No. K2-DA-70554. t R. Hitzemann and H. Loh, data in preparation. 2731
PY - 1973/11/1
Y1 - 1973/11/1
N2 - The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.
AB - The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.
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U2 - 10.1016/0006-2952(73)90133-0
DO - 10.1016/0006-2952(73)90133-0
M3 - Article
C2 - 4763607
AN - SCOPUS:0015821034
SN - 0006-2952
VL - 22
SP - 2731
EP - 2741
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 21
ER -