TY - JOUR
T1 - Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212
AU - Van de Kar, Louis D.
AU - Rittenhouse, Peter A.
AU - O'Connor, Patricia
AU - Palionis, Thomas
AU - Brownfield, Mark S.
AU - Lent, Stephanie J.
AU - Carnes, Molly
AU - Bethea, Cynthia L.
N1 - Funding Information:
The authors thank Ms. KayokoK unimoto and Mr. Joseph Yracheta for their excellentt echnicalassistance. We also thank the followingf or the generousg ifts of drugs: the National Institutef or Drug Abuse (NIDA, Rockville, MD) for cocaine and Merck Sh~r~ and Dohm¢ (West Point PA) for ~K-212, Supported in part by USPHS Grants DA04865 (LDV), MH45812 (LDV and MSB), and AmericanH eart Associationo f MetropolitanC hicago (LDV) and the Veterans Administration( MC).
PY - 1992/8/1
Y1 - 1992/8/1
N2 - This study was undertaken to examine whether several of the hormones that can be released by activation of serotonin receptors will be affected by long-term cocaine administration. Male rats received cocaine injections (15 mg/kg, IP) twice daily for 7 days. Forty-two hr after the last cocaine injection, the rats were challenged with increasing doses (0, 1, 5, 10 mg/kg, IP) of the 5-HT1/5-HT2 agonist MK-212 (6-chloro-2-[1-piperazinyll-pyrazine). The following observations were made: (1) cocaine reduced the rate of body weight gain; (2) cocaine inhibited the stimulatory effect of MK-212 on plasma vasopressin, oxytocin, and prolactin concentrations and on plasma renin activity and concentration; (3) cocaine did not inhibit the stimulatory effect of MK-212 on plasma ACTH or corticosterone concentrations. The data indicate that a wide-spectrum 5-HT (serotonin) agonist such as MK-212 can reveal differential neuroendocrine responses. This effect could be related to cocaine-induced changes in the different 5-HT receptor subtypes that regulate the secretion of these hormones.
AB - This study was undertaken to examine whether several of the hormones that can be released by activation of serotonin receptors will be affected by long-term cocaine administration. Male rats received cocaine injections (15 mg/kg, IP) twice daily for 7 days. Forty-two hr after the last cocaine injection, the rats were challenged with increasing doses (0, 1, 5, 10 mg/kg, IP) of the 5-HT1/5-HT2 agonist MK-212 (6-chloro-2-[1-piperazinyll-pyrazine). The following observations were made: (1) cocaine reduced the rate of body weight gain; (2) cocaine inhibited the stimulatory effect of MK-212 on plasma vasopressin, oxytocin, and prolactin concentrations and on plasma renin activity and concentration; (3) cocaine did not inhibit the stimulatory effect of MK-212 on plasma ACTH or corticosterone concentrations. The data indicate that a wide-spectrum 5-HT (serotonin) agonist such as MK-212 can reveal differential neuroendocrine responses. This effect could be related to cocaine-induced changes in the different 5-HT receptor subtypes that regulate the secretion of these hormones.
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U2 - 10.1016/0006-3223(92)90107-B
DO - 10.1016/0006-3223(92)90107-B
M3 - Article
C2 - 1330009
AN - SCOPUS:0026480856
SN - 0006-3223
VL - 32
SP - 258
EP - 269
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 3
ER -