Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212

Louis D. Van de Kar, Peter A. Rittenhouse, Patricia O'Connor, Thomas Palionis, Mark S. Brownfield, Stephanie J. Lent, Molly Carnes, Cynthia Bethea

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    This study was undertaken to examine whether several of the hormones that can be released by activation of serotonin receptors will be affected by long-term cocaine administration. Male rats received cocaine injections (15 mg/kg, IP) twice daily for 7 days. Forty-two hr after the last cocaine injection, the rats were challenged with increasing doses (0, 1, 5, 10 mg/kg, IP) of the 5-HT1/5-HT2 agonist MK-212 (6-chloro-2-[1-piperazinyll-pyrazine). The following observations were made: (1) cocaine reduced the rate of body weight gain; (2) cocaine inhibited the stimulatory effect of MK-212 on plasma vasopressin, oxytocin, and prolactin concentrations and on plasma renin activity and concentration; (3) cocaine did not inhibit the stimulatory effect of MK-212 on plasma ACTH or corticosterone concentrations. The data indicate that a wide-spectrum 5-HT (serotonin) agonist such as MK-212 can reveal differential neuroendocrine responses. This effect could be related to cocaine-induced changes in the different 5-HT receptor subtypes that regulate the secretion of these hormones.

    Original languageEnglish (US)
    Pages (from-to)258-269
    Number of pages12
    JournalBiological Psychiatry
    Volume32
    Issue number3
    DOIs
    StatePublished - Aug 1 1992

    Fingerprint

    Serotonin Receptor Agonists
    Cocaine
    Injections
    Serotonin Receptors
    Serotonin 5-HT2 Receptor Agonists
    Hormones
    Pyrazines
    Oxytocin
    Corticosterone
    6-chloro-2-(1-piperazinyl)pyrazine
    Vasopressins
    Renin
    Prolactin
    Adrenocorticotropic Hormone
    Weight Gain
    Body Weight

    ASJC Scopus subject areas

    • Biological Psychiatry

    Cite this

    Van de Kar, L. D., Rittenhouse, P. A., O'Connor, P., Palionis, T., Brownfield, M. S., Lent, S. J., ... Bethea, C. (1992). Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biological Psychiatry, 32(3), 258-269. https://doi.org/10.1016/0006-3223(92)90107-B

    Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. / Van de Kar, Louis D.; Rittenhouse, Peter A.; O'Connor, Patricia; Palionis, Thomas; Brownfield, Mark S.; Lent, Stephanie J.; Carnes, Molly; Bethea, Cynthia.

    In: Biological Psychiatry, Vol. 32, No. 3, 01.08.1992, p. 258-269.

    Research output: Contribution to journalArticle

    Van de Kar, LD, Rittenhouse, PA, O'Connor, P, Palionis, T, Brownfield, MS, Lent, SJ, Carnes, M & Bethea, C 1992, 'Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212', Biological Psychiatry, vol. 32, no. 3, pp. 258-269. https://doi.org/10.1016/0006-3223(92)90107-B
    Van de Kar LD, Rittenhouse PA, O'Connor P, Palionis T, Brownfield MS, Lent SJ et al. Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biological Psychiatry. 1992 Aug 1;32(3):258-269. https://doi.org/10.1016/0006-3223(92)90107-B
    Van de Kar, Louis D. ; Rittenhouse, Peter A. ; O'Connor, Patricia ; Palionis, Thomas ; Brownfield, Mark S. ; Lent, Stephanie J. ; Carnes, Molly ; Bethea, Cynthia. / Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. In: Biological Psychiatry. 1992 ; Vol. 32, No. 3. pp. 258-269.
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