Effect of cholinergic agents in Huntington’s disease: A reappraisal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of centrally and peripherally active anticholinergic agents were investigated in four patients with Huntington’s disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results, combined with previous studies, indicate that cholinergic agonists and antagonists that produce sedation may reduce chorea without improving coordination, and suggest that this antichoreic action is independent of their cholinergic actions.

Original languageEnglish (US)
Pages (from-to)932-935
Number of pages4
JournalNeurology
Volume33
Issue number7
StatePublished - 1983

Fingerprint

Huntington Disease
Cholinergic Antagonists
Cholinergic Agents
Chorea
Benztropine
Glycopyrrolate
Cholinergic Agonists
Confusion
Scopolamine Hydrobromide
Ataxia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of cholinergic agents in Huntington’s disease : A reappraisal. / Nutt, John.

In: Neurology, Vol. 33, No. 7, 1983, p. 932-935.

Research output: Contribution to journalArticle

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