TY - JOUR
T1 - Effect of cholinergic agents in Huntington’s disease
T2 - A reappraisal
AU - Nutt, John G.
PY - 1983/7
Y1 - 1983/7
N2 - The effects of centrally and peripherally active anticholinergic agents were investigated in four patients with Huntington’s disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results, combined with previous studies, indicate that cholinergic agonists and antagonists that produce sedation may reduce chorea without improving coordination, and suggest that this antichoreic action is independent of their cholinergic actions.
AB - The effects of centrally and peripherally active anticholinergic agents were investigated in four patients with Huntington’s disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results, combined with previous studies, indicate that cholinergic agonists and antagonists that produce sedation may reduce chorea without improving coordination, and suggest that this antichoreic action is independent of their cholinergic actions.
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U2 - 10.1212/wnl.33.7.932
DO - 10.1212/wnl.33.7.932
M3 - Article
C2 - 6223236
AN - SCOPUS:0020575016
SN - 0028-3878
VL - 33
SP - 932
EP - 935
JO - Neurology
JF - Neurology
IS - 7
ER -