Effect of centrally administered endothelin agonists on systemic and regional blood circulation in the rat

Role of sympathetic nervous system

A. Gulati, A. Kumar, Shaun Morrison, B. T. Shahani

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aims of the present study were to determine (1) the hypotensive and regional circulatory effects of centrally administered endothelin (ET) ET(A) and ET(B) agonists, and (2) the role of the sympathetic nervous system in the mediation of hypotensive effects due to centrally administered ET-1. The systemic haemodynamics and regional blood circulation in urethane anaesthetized rats following intracerebroventricular (i.c.v.) administration of ET-1, ET-2. SRT6b, ET-3 and SRT6c (10, 30 and 90 ng) were determined by a radioactive microsphere technique. The effect of centrally administered ET-1 on sympathetic nerve activity was also analysed. Systemic haemodynamics aria regional blood circulation were determined before (baseline) and 30 min after administration of ET agonists. Cumulative administration of three doses of saline (5 μl, i.c.v. at 30 min intervals) did not produce any significant cardiovascular effects. ET-1, ET-2 and SRT6b produced a decrease in blood pressure (51%, 47% and 41%, respectively) along with a decrease in cardiac output (58%, 60% and 45%, respectively) and stroke volume. Heart rate and total peripheral resistance were not affected, ET-1, ET-2 and SRT6b also produced a significant reduction in blood flow to the brain. kidneys, heart, portal, mesentery and pancreas, gastrointestinal tract (GIT) and musculoskeletal system. The effect of ET-2 on the cardiovascular system was less intense in comparison with ET-1 and SRT6b. Centrally administered specific ET(B) receptor agonists ET-3 and SRT6c did not produce any change in systemic haemodynamics and regional blood flow. Centrally administered ET-1 (90 ng) produced a significant decrease (61%) in sympathetic nerve activity 30 min after drug administration, along with a fall in blood pressure. It is concluded that centrally administered ET(A) agonists produce significant cardiovascular effects mediating through the sympathetic nervous system.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalNeuropeptides
Volume31
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Blood Circulation
Endothelins
Sympathetic Nervous System
Hemodynamics
Neurology
Endothelin-1
Rats
Endothelin-2
Endothelin-3
Blood pressure
Blood
Musculoskeletal system
Endothelin B Receptors
Blood Pressure
Cardiovascular system
Musculoskeletal System
Mesentery
Urethane
Regional Blood Flow
Cardiovascular System

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

Cite this

Effect of centrally administered endothelin agonists on systemic and regional blood circulation in the rat : Role of sympathetic nervous system. / Gulati, A.; Kumar, A.; Morrison, Shaun; Shahani, B. T.

In: Neuropeptides, Vol. 31, No. 4, 1997, p. 301-309.

Research output: Contribution to journalArticle

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