Effect of cell culture conditions on the anticytomegalovirus activity of maribavir

Sunwen Chou; Laura C. Van Wechel; Gail I. Marousek

doi:10.1128/AAC.00207-06

Effect of cell culture conditions on the anticytomegalovirus activity of maribavir

Sunwen Chou, Laura C. Van Wechel, Gail I. Marousek

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

Original language	English (US)
Pages (from-to)	2557-2559
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00207-06
State	Published - Jul 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Effect of cell culture conditions on the anticytomegalovirus activity of maribavir",

abstract = "The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.",

author = "Sunwen Chou and {Van Wechel}, {Laura C.} and Marousek, {Gail I.}",

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AB - The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

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Effect of cell culture conditions on the anticytomegalovirus activity of maribavir

Abstract

ASJC Scopus subject areas

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