Effect of cell culture conditions on the anticytomegalovirus activity of maribavir

Sunwen Chou, Laura C. Van Wechel, Gail I. Marousek

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

Original languageEnglish (US)
Pages (from-to)2557-2559
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number7
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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