Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques

Nona Aghazadeh-Sanai, Jodi L. Downs, Julie A. Mattison, Donald K. Ingram, Steven G. Kohama, Henryk F. Urbanski

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    In this study, we examined the 24-hour plasma melatonin patterns of young adult (∼11 years of age) and old (∼24 years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5 years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2 years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melatonin levels in the young adult females. Taken together, the results fail to show any clear benefit of CR on plasma melatonin levels in old rhesus macaques and may even be detrimental to plasma melatonin levels in young adults.

    Original languageEnglish (US)
    Pages (from-to)213-216
    Number of pages4
    JournalNeurobiology of Aging
    Volume55
    DOIs
    StatePublished - Jul 2017

    Keywords

    • Aging
    • Caloric restriction
    • Circadian
    • Endocrine rhythms
    • Melatonin
    • Primate

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Aging
    • Clinical Neurology
    • Developmental Biology
    • Geriatrics and Gerontology

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