Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques

Nona Aghazadeh-Sanai, Jodi L. Downs, Julie A. Mattison, Donald K. Ingram, Steven Kohama, Henryk Urbanski

    Research output: Contribution to journalArticle

    Abstract

    In this study, we examined the 24-hour plasma melatonin patterns of young adult (∼11 years of age) and old (∼24 years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5 years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2 years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melatonin levels in the young adult females. Taken together, the results fail to show any clear benefit of CR on plasma melatonin levels in old rhesus macaques and may even be detrimental to plasma melatonin levels in young adults.

    Original languageEnglish (US)
    JournalNeurobiology of Aging
    DOIs
    StateAccepted/In press - Feb 2 2017

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    Caloric Restriction
    Melatonin
    Macaca mulatta
    Young Adult

    Keywords

    • Aging
    • Caloric restriction
    • Circadian
    • Endocrine rhythms
    • Melatonin
    • Primate

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Aging
    • Developmental Biology
    • Geriatrics and Gerontology
    • Clinical Neurology

    Cite this

    Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques. / Aghazadeh-Sanai, Nona; Downs, Jodi L.; Mattison, Julie A.; Ingram, Donald K.; Kohama, Steven; Urbanski, Henryk.

    In: Neurobiology of Aging, 02.02.2017.

    Research output: Contribution to journalArticle

    Aghazadeh-Sanai, Nona ; Downs, Jodi L. ; Mattison, Julie A. ; Ingram, Donald K. ; Kohama, Steven ; Urbanski, Henryk. / Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques. In: Neurobiology of Aging. 2017.
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