Effect of bundle branch block on microvolt T-wave alternans and electrophysiologic testing in patients with ischemic cardiomyopathy

Daniel P. Morin, Eran S. Zacks, Andreas C. Mauer, Shaun Ageno, Matthew Janik, Steven M. Markowitz, Suneet Mittal, Sei Iwai, Bindi K. Shah, Bruce B. Lerman, Kenneth M. Stein

Research output: Contribution to journalArticle

22 Scopus citations


Background: T-wave alternans (TWA) and electrophysiology study (EPS) are used for risk stratification for sudden death. Objective: The purpose of the study was to determine the effect of bundle branch block or intraventricular conduction delay on TWA and EPS. Methods: 386 patients with coronary artery disease, nonsustained ventricular tachycardia, and left ventricular ejection fraction ≤40% underwent TWA and EPS, and were followed for 40 ± 19 months. Results: Patients with wide QRS were more likely than narrow QRS patients to have nonnegative TWA (77% vs 63%, P

Original languageEnglish (US)
Pages (from-to)904-912
Number of pages9
JournalHeart Rhythm
Issue number7
Publication statusPublished - Jul 2007
Externally publishedYes



  • Bundle branch block
  • Electrophysiologic study
  • QRS
  • T-wave alternans

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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