Effect of bromocriptine on affect and libido in hyperprolactinemia

M. C.S. Koppelman, B. L. Parry, J. A. Hamilton, S. W. Alagna, D. L. Loriaux

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Six women with primary hyperprolactinemia (mean prolactin level, 50 ng/ml) were matched with six normal women on eight factors influencing life style. Observers blind to endocrine status followed the subjects weekly for 10 weeks. Patients took bromocriptine, 2.5 mg twice daily, or placebo in a randomized double-blind sequence with crossover at 5 weeks. The mean Hamilton score for the patients was compatible with mild depression and higher than that for normal subjects during placebo but not during bromocriptine treatment. Libido was similar in both groups during placebo and bromocriptine. The mean number of orgasms reported per day was lower in patients than in normal subjects during both treatment conditions, although one patient reported orgasms during drug treatment only. Hyperprolactinemia in women may be associated with mild depression and a decrease in orgasmic frequency.

Original languageEnglish (US)
Pages (from-to)1037-1041
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number8
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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