Background and Objective: Brimonidine tartrate 0.5%, a topical alpha2-adrenergic agonist, was administered before and after argon laser trabeculoplasty (ALT) to evaluate its efficacy against postoperative intraocular pressure (IOP) spikes. Patients and Methods: Two randomized, double-masked, vehicle-controlled investigations evaluated four treatment regimens in 471 patients undergoing ALT for glaucoma or ocular hypertension. The combined results are presented. Results: IOP elevations ≥ 10 mmHg occured in 1% (1/122) of the patients who received brimonidine before and after ALT; in 2% (2/119) of those receiving brimonidine before and vehicle after; in 1% (1/114) of those receiving vehicle before and brimonidine after; and in 23% (27/116) of those receiving vehicle before and after (P < .001). Conclusion: The brimonidine regimens were generally effective and well-tolerated ocularly and systemically.
|Original language||English (US)|
|Number of pages||6|
|Journal||Ophthalmic Surgery and Lasers|
|State||Published - Dec 7 1995|
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