TY - JOUR
T1 - Effect of brain growth stages on T‐maze acquisition in mice
AU - DeLuca, John
AU - Bischoff, Hank
AU - Kelman, Stanley
AU - Lavooy, Maria
AU - Phillips, Tamara
AU - Posch, Robert
AU - Wolf, Patricia
AU - Hahn, Martin
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1982/1
Y1 - 1982/1
N2 - Recently, it has been shown that brain growth is characterized by periods of especially large increases in growth, with “plateaus” in growth between these “spurt” periods. In humans, these spurts in brain growth are correlated with spurts in mind growth, collectively termed phrenoblysis. Brain growth spurts in rodents occur at 0–6, 8–12, and 17–23 days of age with plateaus in‐between. We examined two questions. First, are there differences in learning ability associated with spurts and plateaus in brain growth? Second, can learning during these stages be altered through genetic and environmental manipulations? We employed the high and low lines of the Fuller brain weight selection mice, which are known to have different developmental patterns, and early handling procedures, known to alter growth rates. The results showed that animals tested during a proposed brain growth spurt were superior to animals tested during a brain growth plateau in learning a shock‐escape T‐maze.
AB - Recently, it has been shown that brain growth is characterized by periods of especially large increases in growth, with “plateaus” in growth between these “spurt” periods. In humans, these spurts in brain growth are correlated with spurts in mind growth, collectively termed phrenoblysis. Brain growth spurts in rodents occur at 0–6, 8–12, and 17–23 days of age with plateaus in‐between. We examined two questions. First, are there differences in learning ability associated with spurts and plateaus in brain growth? Second, can learning during these stages be altered through genetic and environmental manipulations? We employed the high and low lines of the Fuller brain weight selection mice, which are known to have different developmental patterns, and early handling procedures, known to alter growth rates. The results showed that animals tested during a proposed brain growth spurt were superior to animals tested during a brain growth plateau in learning a shock‐escape T‐maze.
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U2 - 10.1002/dev.420150112
DO - 10.1002/dev.420150112
M3 - Article
C2 - 7054019
AN - SCOPUS:0020060806
SN - 0012-1630
VL - 15
SP - 81
EP - 88
JO - Developmental Psychobiology
JF - Developmental Psychobiology
IS - 1
ER -