Effect of blood vessel diameter on relative blood flow estimate in Doppler optical coherence tomography algorithms

Jason Tokayer, David Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In vivo measurement of blood flow in the retina has been made possible with the advent of Fourier domain optical coherence tomography (OCT). Doppler OCT has seen many advances in recent years in algorithms used for quantifying blood flow. We compare the relative retinal blood flow estimates as measured by the standard phase-resolved (PR) algorithm and the more recent moving-scatterer- sensitive (MSS) algorithm as a function of vessel size. We find that the PR-to-MSS flow ratio significantly decreases with decreasing vessel diameter. We also develop a simulation to approximate the scattering from blood cells in tissue and compare the relative blood flow estimates. The flow ratio measured with simulation closely matches that found in vivo. Our simulation predicts that whereas PR underestimates the flow, MSS overestimates it. Our simulation may help to correct for algorithm bias in in vivo retinal flow estimates.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
DOIs
StatePublished - Apr 12 2011
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Keywords

  • Doppler
  • Optical coherence tomography
  • moving-scatterer- sensitive
  • phase-resolved

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tokayer, J., & Huang, D. (2011). Effect of blood vessel diameter on relative blood flow estimate in Doppler optical coherence tomography algorithms. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV [78892X] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7889). https://doi.org/10.1117/12.874231