Effect of Angiotensin II on Ovine Placental Blood Flow

Debra Anderson; Anne Berssenbrugge; Terrance Phernetton; John H.G. Rankin

doi:10.3181/00379727-158-40138

Effect of Angiotensin II on Ovine Placental Blood Flow

Debra Anderson, Anne Berssenbrugge, Terrance Phernetton, John H.G. Rankin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The injection of 10 μg angiotensin II to 5 near-term sheep caused significant increases in the renal, uterine and placental vascular resistances. After pretreatment with 10 mg/kg indomethacin the injection of 10 μg angiotensin II caused a significantly greater change in the vascular resistance of the kidneys and uterus. The response of the placental vasculature to angiotensin II was not affected by the pretreatment. Endogenous prostaglandins may play a role in modulating the response of the renal and uterine vascular beds to angiotensin II but this study provides no evidence to support the hypothesis that prostaglandins modulate the placental response to angiotensin II.

Original language	English (US)
Pages (from-to)	54-58
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	158
Issue number	1
DOIs	https://doi.org/10.3181/00379727-158-40138
State	Published - May 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Effect of Angiotensin II on Ovine Placental Blood Flow",

abstract = "The injection of 10 μg angiotensin II to 5 near-term sheep caused significant increases in the renal, uterine and placental vascular resistances. After pretreatment with 10 mg/kg indomethacin the injection of 10 μg angiotensin II caused a significantly greater change in the vascular resistance of the kidneys and uterus. The response of the placental vasculature to angiotensin II was not affected by the pretreatment. Endogenous prostaglandins may play a role in modulating the response of the renal and uterine vascular beds to angiotensin II but this study provides no evidence to support the hypothesis that prostaglandins modulate the placental response to angiotensin II.",

author = "Debra Anderson and Anne Berssenbrugge and Terrance Phernetton and Rankin, {John H.G.}",

note = "Funding Information: Supported by NICHD Grant No. HD06736. 5 1978 158 1 54 58 ",

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AU - Rankin, John H.G.

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AB - The injection of 10 μg angiotensin II to 5 near-term sheep caused significant increases in the renal, uterine and placental vascular resistances. After pretreatment with 10 mg/kg indomethacin the injection of 10 μg angiotensin II caused a significantly greater change in the vascular resistance of the kidneys and uterus. The response of the placental vasculature to angiotensin II was not affected by the pretreatment. Endogenous prostaglandins may play a role in modulating the response of the renal and uterine vascular beds to angiotensin II but this study provides no evidence to support the hypothesis that prostaglandins modulate the placental response to angiotensin II.

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Effect of Angiotensin II on Ovine Placental Blood Flow

Abstract

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