Effect of an Opiate Antagonist on Movement Disorders

John Nutt, Arnold J. Rosin, Toomas Eisler, Donald B. Calne, Thomas N. Chase

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

Original languageEnglish (US)
Pages (from-to)810-811
Number of pages2
JournalArchives of Neurology
Volume35
Issue number12
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Opiate Alkaloids
Movement Disorders
Naltrexone
Opioid Peptides
Huntington Disease
Parkinsonian Disorders
Antagonist
Dose
Experiment
Animals

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of an Opiate Antagonist on Movement Disorders. / Nutt, John; Rosin, Arnold J.; Eisler, Toomas; Calne, Donald B.; Chase, Thomas N.

In: Archives of Neurology, Vol. 35, No. 12, 1978, p. 810-811.

Research output: Contribution to journalArticle

Nutt, J, Rosin, AJ, Eisler, T, Calne, DB & Chase, TN 1978, 'Effect of an Opiate Antagonist on Movement Disorders', Archives of Neurology, vol. 35, no. 12, pp. 810-811. https://doi.org/10.1001/archneur.1978.00500360034006
Nutt, John ; Rosin, Arnold J. ; Eisler, Toomas ; Calne, Donald B. ; Chase, Thomas N. / Effect of an Opiate Antagonist on Movement Disorders. In: Archives of Neurology. 1978 ; Vol. 35, No. 12. pp. 810-811.
@article{413b4e1687d64acf93e2aef2fc3f4dfe,
title = "Effect of an Opiate Antagonist on Movement Disorders",
abstract = "Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.",
author = "John Nutt and Rosin, {Arnold J.} and Toomas Eisler and Calne, {Donald B.} and Chase, {Thomas N.}",
year = "1978",
doi = "10.1001/archneur.1978.00500360034006",
language = "English (US)",
volume = "35",
pages = "810--811",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - Effect of an Opiate Antagonist on Movement Disorders

AU - Nutt, John

AU - Rosin, Arnold J.

AU - Eisler, Toomas

AU - Calne, Donald B.

AU - Chase, Thomas N.

PY - 1978

Y1 - 1978

N2 - Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

AB - Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

UR - http://www.scopus.com/inward/record.url?scp=0018172807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018172807&partnerID=8YFLogxK

U2 - 10.1001/archneur.1978.00500360034006

DO - 10.1001/archneur.1978.00500360034006

M3 - Article

C2 - 152622

AN - SCOPUS:0018172807

VL - 35

SP - 810

EP - 811

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 12

ER -