Effect of an Opiate Antagonist on Movement Disorders

John G. Nutt; Arnold J. Rosin; Toomas Eisler; Donald B. Calne; Thomas N. Chase

doi:10.1001/archneur.1978.00500360034006

Effect of an Opiate Antagonist on Movement Disorders

John G. Nutt, Arnold J. Rosin, Toomas Eisler, Donald B. Calne, Thomas N. Chase

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

Original language	English (US)
Pages (from-to)	810-811
Number of pages	2
Journal	Archives of Neurology
Volume	35
Issue number	12
DOIs	https://doi.org/10.1001/archneur.1978.00500360034006
State	Published - Dec 1978
Externally published	Yes

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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10.1001/archneur.1978.00500360034006

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title = "Effect of an Opiate Antagonist on Movement Disorders",

abstract = "Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.",

author = "Nutt, {John G.} and Rosin, {Arnold J.} and Toomas Eisler and Calne, {Donald B.} and Chase, {Thomas N.}",

year = "1978",

month = dec,

doi = "10.1001/archneur.1978.00500360034006",

language = "English (US)",

volume = "35",

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journal = "Archives of Neurology",

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AU - Rosin, Arnold J.

AU - Eisler, Toomas

AU - Calne, Donald B.

AU - Chase, Thomas N.

PY - 1978/12

Y1 - 1978/12

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AB - Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

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Effect of an Opiate Antagonist on Movement Disorders

Abstract

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