Effect of an obesogenic diet on circadian activity and serum hormones in old monkeys

    Research output: Contribution to journalArticle

    Abstract

    Like women, old female rhesus macaques undergo menopause and show many of the same age-associated changes, including perturbed activity/rest cycles and altered circulating levels of many hormones. Previous studies showed that administration of an estrogen agonist increased activity in female monkeys, that hormone therapy (HT) increased activity in postmenopausal women and that obesity decreased activity in women. The present study sought to determine if postmenopausal activity and circulating hormone levels also respond to HT when monkeys are fed a high-fat, high-sugar Western style diet (WSD). Old female rhesus macaques were ovo-hysterectomized (OvH) to induce surgical menopause and fed a WSD for 2 years. Half of the animals received estradiol-17β (E), beginning immediately after OvH, while the other half received placebo. Animals in both groups showed an increase in body weight and a decrease in overall activity levels. These changes were associated with a rise in both daytime and nocturnal serum leptin concentrations, but there was no change in serum concentrations of either cortisol or dehydroepiandrosterone sulfate (DHEAS). These data suggest that 2 years of HT has little or no effect on locomotor activity or circadian hormone patterns in menopausal macaques fed an obesogenic diet.

    Original languageEnglish (US)
    Pages (from-to)380-383
    Number of pages4
    JournalEndocrine Connections
    Volume6
    Issue number6
    DOIs
    StatePublished - Aug 1 2017

    Fingerprint

    Haplorhini
    Hormones
    Diet
    Serum
    Menopause
    Macaca mulatta
    Activity Cycles
    Dehydroepiandrosterone Sulfate
    Macaca
    Locomotion
    Leptin
    Estradiol
    Estrogens
    Therapeutics
    Obesity
    Fats
    Placebos
    Body Weight

    Keywords

    • Cortisol
    • DHEAS
    • Estrogen
    • Leptin
    • Melatonin

    ASJC Scopus subject areas

    • Endocrinology
    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Effect of an obesogenic diet on circadian activity and serum hormones in old monkeys. / Urbanski, Henryk; Mueller, Kevin; Bethea, Cynthia.

    In: Endocrine Connections, Vol. 6, No. 6, 01.08.2017, p. 380-383.

    Research output: Contribution to journalArticle

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