Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh; Robert J. Hitzemann; E. Leong Way

doi:10.1016/0024-3205(73)90171-9

Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh, Robert J. Hitzemann, E. Leong Way

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [¹⁴C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [¹⁴C]-tyrosine to the [¹⁴C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [¹⁴C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Life Sciences
Volume	12
Issue number	1 PART 1
DOIs	https://doi.org/10.1016/0024-3205(73)90171-9
State	Published - Jan 3 1973
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(73)90171-9

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title = "Effect of acute morphine administration on the metabolism of brain catecholamines",

abstract = "The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.",

author = "Loh, {Horace H.} and Hitzemann, {Robert J.} and {Leong Way}, E.",

note = "Funding Information: ACKNOWLEDGEMENTS This study was supported in part by grants MH-19768 (HHL), MH-17017 and GM-01839 (ELW). The secretarial assistance of Miss Barbara Halperin is also gratefully acknowledged. We are in debted to Dr. A, K, S. Ho for the determination of the brain tyrosine levels, Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1973",

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doi = "10.1016/0024-3205(73)90171-9",

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AU - Loh, Horace H.

AU - Hitzemann, Robert J.

AU - Leong Way, E.

N1 - Funding Information: ACKNOWLEDGEMENTS This study was supported in part by grants MH-19768 (HHL), MH-17017 and GM-01839 (ELW). The secretarial assistance of Miss Barbara Halperin is also gratefully acknowledged. We are in debted to Dr. A, K, S. Ho for the determination of the brain tyrosine levels, Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1973/1/3

Y1 - 1973/1/3

N2 - The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

AB - The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

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Effect of acute morphine administration on the metabolism of brain catecholamines

Abstract

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