Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh, Robert Hitzemann, E. Leong Way

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalLife Sciences
Volume12
Issue number1 PART 1
DOIs
StatePublished - Jan 3 1973
Externally publishedYes

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Metabolism
Morphine
Catecholamines
Brain
Tyrosine
Naloxone

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Effect of acute morphine administration on the metabolism of brain catecholamines. / Loh, Horace H.; Hitzemann, Robert; Leong Way, E.

In: Life Sciences, Vol. 12, No. 1 PART 1, 03.01.1973, p. 33-41.

Research output: Contribution to journalArticle

Loh, Horace H. ; Hitzemann, Robert ; Leong Way, E. / Effect of acute morphine administration on the metabolism of brain catecholamines. In: Life Sciences. 1973 ; Vol. 12, No. 1 PART 1. pp. 33-41.
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