Effect of acute morphine administration on the metabolism of brain catecholamines

Horace H. Loh, Robert J. Hitzemann, E. Leong Way

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The effects of sub-analgetic and analgetic doses of morphine (5-20 mg/kg) on the metabolism of intravenously administered [14C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [14C]-tyrosine to the [14C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [14C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalLife Sciences
Issue number1 PART 1
StatePublished - Jan 3 1973


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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