Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep

J. M. Bissonnette, A. R. Hohimer, B. S. Richardson, C. M. Machida

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Abstract

Studies were carried out in 11 fetal sheep four days after surgery for insertion of catheters and electrocortical leads. After a 3 h control period an insulin infusion was given to the ewe and maintained for the next 4 h. Fetal arterial glucose fell from 0.85± 0.10 to 0.57 ± 0.06 mM (SEM) while oxygen content was unchanged (3.80 ± 0.24 to 3.75 ± 0.21 mM). Cerebral uptake of oxygen and glucose were determined from samples drawn simultaneously from the axillary artery and sagittal vein and cerebral blood flow (microsphere technique). There was no significant change in uptake of either oxygen or glucose by the fetal brain. We conclude that a rapid fall in fetal glucose levels with no change in oxygen content does not result in decrease in cerebral metabolism over a short term.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Developmental Physiology
Volume7
Issue number6
StatePublished - Dec 1 1985

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ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Bissonnette, J. M., Hohimer, A. R., Richardson, B. S., & Machida, C. M. (1985). Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep. Journal of Developmental Physiology, 7(6), 421-426.