Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep

J. M. Bissonnette, Alan (Roger) Hohimer, B. S. Richardson, C. M. Machida

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Studies were carried out in 11 fetal sheep four days after surgery for insertion of catheters and electrocortical leads. After a 3 h control period an insulin infusion was given to the ewe and maintained for the next 4 h. Fetal arterial glucose fell from 0.85± 0.10 to 0.57 ± 0.06 mM (SEM) while oxygen content was unchanged (3.80 ± 0.24 to 3.75 ± 0.21 mM). Cerebral uptake of oxygen and glucose were determined from samples drawn simultaneously from the axillary artery and sagittal vein and cerebral blood flow (microsphere technique). There was no significant change in uptake of either oxygen or glucose by the fetal brain. We conclude that a rapid fall in fetal glucose levels with no change in oxygen content does not result in decrease in cerebral metabolism over a short term.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Developmental Physiology
Volume7
Issue number6
StatePublished - 1985

Fingerprint

Hypoglycemia
Sheep
Oxygen
Glucose
Cerebrovascular Circulation
Axillary Artery
Ambulatory Surgical Procedures
Microspheres
Veins
Catheters
Insulin
Brain

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Bissonnette, J. M., Hohimer, A. R., Richardson, B. S., & Machida, C. M. (1985). Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep. Journal of Developmental Physiology, 7(6), 421-426.

Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep. / Bissonnette, J. M.; Hohimer, Alan (Roger); Richardson, B. S.; Machida, C. M.

In: Journal of Developmental Physiology, Vol. 7, No. 6, 1985, p. 421-426.

Research output: Contribution to journalArticle

Bissonnette, JM, Hohimer, AR, Richardson, BS & Machida, CM 1985, 'Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep', Journal of Developmental Physiology, vol. 7, no. 6, pp. 421-426.
Bissonnette JM, Hohimer AR, Richardson BS, Machida CM. Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep. Journal of Developmental Physiology. 1985;7(6):421-426.
Bissonnette, J. M. ; Hohimer, Alan (Roger) ; Richardson, B. S. ; Machida, C. M. / Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep. In: Journal of Developmental Physiology. 1985 ; Vol. 7, No. 6. pp. 421-426.
@article{400d1d97e7f64fb592bd7dd4f783ac1e,
title = "Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep",
abstract = "Studies were carried out in 11 fetal sheep four days after surgery for insertion of catheters and electrocortical leads. After a 3 h control period an insulin infusion was given to the ewe and maintained for the next 4 h. Fetal arterial glucose fell from 0.85± 0.10 to 0.57 ± 0.06 mM (SEM) while oxygen content was unchanged (3.80 ± 0.24 to 3.75 ± 0.21 mM). Cerebral uptake of oxygen and glucose were determined from samples drawn simultaneously from the axillary artery and sagittal vein and cerebral blood flow (microsphere technique). There was no significant change in uptake of either oxygen or glucose by the fetal brain. We conclude that a rapid fall in fetal glucose levels with no change in oxygen content does not result in decrease in cerebral metabolism over a short term.",
author = "Bissonnette, {J. M.} and Hohimer, {Alan (Roger)} and Richardson, {B. S.} and Machida, {C. M.}",
year = "1985",
language = "English (US)",
volume = "7",
pages = "421--426",
journal = "Journal of Developmental Physiology",
issn = "0141-9846",
number = "6",

}

TY - JOUR

T1 - Effect of acute hypoglycaemia on cerebral metabolic rate in fetal sheep

AU - Bissonnette, J. M.

AU - Hohimer, Alan (Roger)

AU - Richardson, B. S.

AU - Machida, C. M.

PY - 1985

Y1 - 1985

N2 - Studies were carried out in 11 fetal sheep four days after surgery for insertion of catheters and electrocortical leads. After a 3 h control period an insulin infusion was given to the ewe and maintained for the next 4 h. Fetal arterial glucose fell from 0.85± 0.10 to 0.57 ± 0.06 mM (SEM) while oxygen content was unchanged (3.80 ± 0.24 to 3.75 ± 0.21 mM). Cerebral uptake of oxygen and glucose were determined from samples drawn simultaneously from the axillary artery and sagittal vein and cerebral blood flow (microsphere technique). There was no significant change in uptake of either oxygen or glucose by the fetal brain. We conclude that a rapid fall in fetal glucose levels with no change in oxygen content does not result in decrease in cerebral metabolism over a short term.

AB - Studies were carried out in 11 fetal sheep four days after surgery for insertion of catheters and electrocortical leads. After a 3 h control period an insulin infusion was given to the ewe and maintained for the next 4 h. Fetal arterial glucose fell from 0.85± 0.10 to 0.57 ± 0.06 mM (SEM) while oxygen content was unchanged (3.80 ± 0.24 to 3.75 ± 0.21 mM). Cerebral uptake of oxygen and glucose were determined from samples drawn simultaneously from the axillary artery and sagittal vein and cerebral blood flow (microsphere technique). There was no significant change in uptake of either oxygen or glucose by the fetal brain. We conclude that a rapid fall in fetal glucose levels with no change in oxygen content does not result in decrease in cerebral metabolism over a short term.

UR - http://www.scopus.com/inward/record.url?scp=0022216076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022216076&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 421

EP - 426

JO - Journal of Developmental Physiology

JF - Journal of Developmental Physiology

SN - 0141-9846

IS - 6

ER -