Abstract
The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepin e maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses greater than 0.1 mg/kg, i.m. Although Y-931 significantly increased total dystonia scores (the sum of 15 to 360 min after injection) at doses greater than 0.5 mg/kg, i.m., the scores did not exceed 20, up to a dose of 1.0 mg/kg, i.m. and lacked a dose-response relationship. The present result suggests that Y-931 is predicted to have a low risk of extrapyramidal side effects.
Original language | English (US) |
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Pages (from-to) | 364-366 |
Number of pages | 3 |
Journal | Journal of Pharmacological Sciences |
Volume | 93 |
Issue number | 3 |
DOIs | |
State | Published - Nov 2003 |
Keywords
- Dystonia
- Monkey
- Y-931
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology