Effect of a novel potential atypical antipsychotic drug, Y-931, in producing dystonia in Cebus monkeys

Yasuyuki Shiigi, Jun Ichi Maeda, Hiroshi Yasumatsu, Hiroshi Tanaka, Daniel E. Casey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepin e maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses greater than 0.1 mg/kg, i.m. Although Y-931 significantly increased total dystonia scores (the sum of 15 to 360 min after injection) at doses greater than 0.5 mg/kg, i.m., the scores did not exceed 20, up to a dose of 1.0 mg/kg, i.m. and lacked a dose-response relationship. The present result suggests that Y-931 is predicted to have a low risk of extrapyramidal side effects.

Original languageEnglish (US)
Pages (from-to)364-366
Number of pages3
JournalJournal of Pharmacological Sciences
Volume93
Issue number3
DOIs
StatePublished - Nov 1 2003

Keywords

  • Dystonia
  • Monkey
  • Y-931

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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