Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

U. Noring; U. Juul Povlsen; D. E. Casey; J. Gerlach

doi:10.1007/BF00431469

Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

U. Noring, U. Juul Povlsen, D. E. Casey, J. Gerlach

Pediatrics

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Abstract

RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5-4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatmetn with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.

Original language	English (US)
Pages (from-to)	569-571
Number of pages	3
Journal	Psychopharmacology
Volume	84
Issue number	4
DOIs	https://doi.org/10.1007/BF00431469
State	Published - Dec 1984

Keywords

Cholinomimetics
Parkinsonism
RS 86
Tardive dyskinesia

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00431469

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title = "Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism",

abstract = "RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5-4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatmetn with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.",

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author = "U. Noring and {Juul Povlsen}, U. and Casey, {D. E.} and J. Gerlach",

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T1 - Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

AU - Noring, U.

AU - Juul Povlsen, U.

AU - Casey, D. E.

AU - Gerlach, J.

PY - 1984/12

Y1 - 1984/12

N2 - RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5-4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatmetn with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.

AB - RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5-4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatmetn with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.

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Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

Abstract

Keywords

ASJC Scopus subject areas

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