Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine

Anthony E. Pusateri, Simon McCarthy, Kenton Gregory, Richard A. Harris, Luis Cardenas, Albert T. McManus, Cleon W. Goodwin

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background: Hemorrhage is a leading cause of death from trauma. An advanced hemostatic dressing could augment available hemostatic methods. We studied the effects of a new chitosan dressing on blood loss, survival, and fluid use after severe hepatic injury in swine. Methods: Swine received chitosan dressings or gauze sponges. Standardized, severe liver injuries were induced. After 30 seconds, dressings were applied and resuscitation initiated. Blood loss, hemostasis, resuscitation volume, and 60-minute survival were quantified. Results: Posttreatment blood loss was reduced (p <0.01) in the chitosan group (264 mL; 95% confidence interval [CI], 82-852 mL) compared with the gauze group (2,879 mL; 95% CI, 788-10,513 mL). Fluid use was reduced (p = 0.03) in the chitosan group (1,793 mL; 95% CI, 749-4,291) compared with the gauze group (6,614 mL; 95% CI, 2,519-17,363 mL). Survival was seven of eight and two of even in the chitosan and gauze groups (p = 0.04), respectively. Hemostasis was improved in the chitosan group (p = 0.03). Conclusion: A chitosan dressing reduced hemorrhage and improved survival after severe liver injury in swine. Further studies are warranted.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Chitosan
Hemostatics
Bandages
Swine
Hemorrhage
Liver
Wounds and Injuries
Confidence Intervals
Hemostasis
Resuscitation
Porifera
Cause of Death

Keywords

  • Chitosan
  • Dressing
  • Hemorrhage
  • Hemostasis
  • Liver
  • Swine
  • Trauma
  • Venous

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. / Pusateri, Anthony E.; McCarthy, Simon; Gregory, Kenton; Harris, Richard A.; Cardenas, Luis; McManus, Albert T.; Goodwin, Cleon W.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 54, No. 1, 01.01.2003, p. 177-182.

Research output: Contribution to journalArticle

Pusateri, Anthony E. ; McCarthy, Simon ; Gregory, Kenton ; Harris, Richard A. ; Cardenas, Luis ; McManus, Albert T. ; Goodwin, Cleon W. / Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. In: Journal of Trauma - Injury, Infection and Critical Care. 2003 ; Vol. 54, No. 1. pp. 177-182.
@article{d017ea7f8ec94f3a958deb4da08587bc,
title = "Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine",
abstract = "Background: Hemorrhage is a leading cause of death from trauma. An advanced hemostatic dressing could augment available hemostatic methods. We studied the effects of a new chitosan dressing on blood loss, survival, and fluid use after severe hepatic injury in swine. Methods: Swine received chitosan dressings or gauze sponges. Standardized, severe liver injuries were induced. After 30 seconds, dressings were applied and resuscitation initiated. Blood loss, hemostasis, resuscitation volume, and 60-minute survival were quantified. Results: Posttreatment blood loss was reduced (p <0.01) in the chitosan group (264 mL; 95{\%} confidence interval [CI], 82-852 mL) compared with the gauze group (2,879 mL; 95{\%} CI, 788-10,513 mL). Fluid use was reduced (p = 0.03) in the chitosan group (1,793 mL; 95{\%} CI, 749-4,291) compared with the gauze group (6,614 mL; 95{\%} CI, 2,519-17,363 mL). Survival was seven of eight and two of even in the chitosan and gauze groups (p = 0.04), respectively. Hemostasis was improved in the chitosan group (p = 0.03). Conclusion: A chitosan dressing reduced hemorrhage and improved survival after severe liver injury in swine. Further studies are warranted.",
keywords = "Chitosan, Dressing, Hemorrhage, Hemostasis, Liver, Swine, Trauma, Venous",
author = "Pusateri, {Anthony E.} and Simon McCarthy and Kenton Gregory and Harris, {Richard A.} and Luis Cardenas and McManus, {Albert T.} and Goodwin, {Cleon W.}",
year = "2003",
month = "1",
day = "1",
doi = "10.1097/00005373-200301000-00023",
language = "English (US)",
volume = "54",
pages = "177--182",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine

AU - Pusateri, Anthony E.

AU - McCarthy, Simon

AU - Gregory, Kenton

AU - Harris, Richard A.

AU - Cardenas, Luis

AU - McManus, Albert T.

AU - Goodwin, Cleon W.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Background: Hemorrhage is a leading cause of death from trauma. An advanced hemostatic dressing could augment available hemostatic methods. We studied the effects of a new chitosan dressing on blood loss, survival, and fluid use after severe hepatic injury in swine. Methods: Swine received chitosan dressings or gauze sponges. Standardized, severe liver injuries were induced. After 30 seconds, dressings were applied and resuscitation initiated. Blood loss, hemostasis, resuscitation volume, and 60-minute survival were quantified. Results: Posttreatment blood loss was reduced (p <0.01) in the chitosan group (264 mL; 95% confidence interval [CI], 82-852 mL) compared with the gauze group (2,879 mL; 95% CI, 788-10,513 mL). Fluid use was reduced (p = 0.03) in the chitosan group (1,793 mL; 95% CI, 749-4,291) compared with the gauze group (6,614 mL; 95% CI, 2,519-17,363 mL). Survival was seven of eight and two of even in the chitosan and gauze groups (p = 0.04), respectively. Hemostasis was improved in the chitosan group (p = 0.03). Conclusion: A chitosan dressing reduced hemorrhage and improved survival after severe liver injury in swine. Further studies are warranted.

AB - Background: Hemorrhage is a leading cause of death from trauma. An advanced hemostatic dressing could augment available hemostatic methods. We studied the effects of a new chitosan dressing on blood loss, survival, and fluid use after severe hepatic injury in swine. Methods: Swine received chitosan dressings or gauze sponges. Standardized, severe liver injuries were induced. After 30 seconds, dressings were applied and resuscitation initiated. Blood loss, hemostasis, resuscitation volume, and 60-minute survival were quantified. Results: Posttreatment blood loss was reduced (p <0.01) in the chitosan group (264 mL; 95% confidence interval [CI], 82-852 mL) compared with the gauze group (2,879 mL; 95% CI, 788-10,513 mL). Fluid use was reduced (p = 0.03) in the chitosan group (1,793 mL; 95% CI, 749-4,291) compared with the gauze group (6,614 mL; 95% CI, 2,519-17,363 mL). Survival was seven of eight and two of even in the chitosan and gauze groups (p = 0.04), respectively. Hemostasis was improved in the chitosan group (p = 0.03). Conclusion: A chitosan dressing reduced hemorrhage and improved survival after severe liver injury in swine. Further studies are warranted.

KW - Chitosan

KW - Dressing

KW - Hemorrhage

KW - Hemostasis

KW - Liver

KW - Swine

KW - Trauma

KW - Venous

UR - http://www.scopus.com/inward/record.url?scp=0037243875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037243875&partnerID=8YFLogxK

U2 - 10.1097/00005373-200301000-00023

DO - 10.1097/00005373-200301000-00023

M3 - Article

VL - 54

SP - 177

EP - 182

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 1

ER -