EEG slow waves in traumatic brain injury: Convergent findings in mouse and man

Mo H. Modarres, Nicholas N. Kuzma, Tracy Kretzmer, Allan I. Pack, Miranda Lim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI). Methods We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data. We then used this method to quantify EEG-based slow waves during sleep and wake states in both mouse and human subjects with mTBI. A modified coherence index that accounts for information from multiple channels was calculated as a measure of slow wave synchrony. Results Brain-injured mice showed significantly higher theta:alpha amplitude ratios and significantly more slow waves during spontaneous wakefulness and during prolonged sleep deprivation, compared to sham-injured control mice. Human subjects with mTBI showed significantly higher theta:beta amplitude ratios and significantly more EEG slow waves while awake compared to age-matched control subjects. We then quantified the global coherence index of slow waves across several EEG channels in human subjects. Individuals with mTBI showed significantly less EEG global coherence compared to control subjects while awake, but not during sleep. EEG global coherence was significantly correlated with severity of post-concussive symptoms (as assessed by the Neurobehavioral Symptom Inventory scale). Conclusion and implications Taken together, our data from both mouse and human studies suggest that EEG slow wave quantity and the global coherence index of slow waves may represent a sensitive marker for the diagnosis and prognosis of mTBI and post-concussive symptoms.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalNeurobiology of Sleep and Circadian Rhythms
Volume2
DOIs
StatePublished - Jan 1 2017

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Electroencephalography
Brain Concussion
Post-Concussion Syndrome
Sleep
Traumatic Brain Injury
Sleep Deprivation
Wakefulness
Brain
Pressure
Equipment and Supplies

Keywords

  • Coherence
  • EEG
  • Sleep
  • Slow waves
  • Translational
  • Traumatic brain injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

EEG slow waves in traumatic brain injury : Convergent findings in mouse and man. / Modarres, Mo H.; Kuzma, Nicholas N.; Kretzmer, Tracy; Pack, Allan I.; Lim, Miranda.

In: Neurobiology of Sleep and Circadian Rhythms, Vol. 2, 01.01.2017, p. 59-70.

Research output: Contribution to journalArticle

Modarres, Mo H. ; Kuzma, Nicholas N. ; Kretzmer, Tracy ; Pack, Allan I. ; Lim, Miranda. / EEG slow waves in traumatic brain injury : Convergent findings in mouse and man. In: Neurobiology of Sleep and Circadian Rhythms. 2017 ; Vol. 2. pp. 59-70.
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