Ectopic impulse generation in demyelinated axons

Effects of PaCO2, pH, and disodium edetate

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Demyelinating lesions in the trigeminal root were produced by chronic implantation of chromic suture in 12 cats. Two types of abnormal repetitive action potential generation were recorded from demyelinated fibers: reflected spikes and afterdischarge. Both types of abnormal impulse generation were increased by hypocalcemia induced by disodium edetate infusion, hypocapnia produced by hyperventilation, and, to a lesser extent, alkalosis secondary to sodium bicarbonate administration. This hyperexcitability of fibers could be inherited by hypoventilation with elevation of PaCO2 or by calcium chloride administration. These results may help explain the pathophysiological basis of paroxysmal symptoms in multiple sclerosis and other disorders in which demyelination is a prominent feature.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalAnnals of Neurology
Volume9
Issue number4
StatePublished - 1981
Externally publishedYes

Fingerprint

Hypocapnia
Hypoventilation
Alkalosis
Calcium Chloride
Sodium Bicarbonate
Hyperventilation
Hypocalcemia
Demyelinating Diseases
Sutures
Action Potentials
Multiple Sclerosis
Axons
Cats

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ectopic impulse generation in demyelinated axons : Effects of PaCO2, pH, and disodium edetate. / Burchiel, Kim.

In: Annals of Neurology, Vol. 9, No. 4, 1981, p. 378-383.

Research output: Contribution to journalArticle

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