Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro: comparison of clonal strains from carcinomas of lung and placenta

J. M. Lieblich, B. D. Weintraub, G. H. Krauth, Peter Kohler, A. S. Rabson, S. W. Rosen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Rates of secretion in vitro of human chorionic gonadotropin (HCG) and its subunits α and β by established clonal cell lines of a bronchogenic carcinoma (ChaGo) and a choriocarcinoma (JEG) were compared. Clones showed the highest secretion rates of either HCG or its subunits were studied: ChaGo K1, a new clonal strain, and ChaGo C5 and JEG 3, two previously reported clonal lines. Cells were grown under identical conditions in the same laboratory. Hormone and subunit concentrations were measured by radioimmunoassays. ChaGo K1 and ChaGo C5 secreted only α subunit whereas JEG 3 secreted only HCG. Average peak secretion rates in picomoles/day/mg protein were: for ChaGo K1, HCG

Original languageEnglish (US)
Pages (from-to)911-917
Number of pages7
JournalJournal of the National Cancer Institute
Volume56
Issue number5
StatePublished - 1976
Externally publishedYes

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Chorionic Gonadotropin
Placenta
Carcinoma
Lung
Choriocarcinoma
Bronchogenic Carcinoma
Radioimmunoassay
Clone Cells
Hormones
Cell Line
In Vitro Techniques
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro : comparison of clonal strains from carcinomas of lung and placenta. / Lieblich, J. M.; Weintraub, B. D.; Krauth, G. H.; Kohler, Peter; Rabson, A. S.; Rosen, S. W.

In: Journal of the National Cancer Institute, Vol. 56, No. 5, 1976, p. 911-917.

Research output: Contribution to journalArticle

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