Echoplanar chemical shift imaging

A. R. Guimaraes, J. R. Baker, B. G. Jenkins, P. L. Lee, R. M. Weisskoff, B. R. Rosen, R. G. González

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A novel method of chemical shift imaging utilizing echoplanar imaging (EPI) has been developed for the purpose of improving the spatial resolution of metabolite images for the specific goal of high spatial resolution mapping of neuronal content. An EPI sequence was modified to allow temporal offsets of the 180°refocusing pulse that encode the chemical shift information into the phase of the signal. Implementation of this method on 1.5 and 3 T human imagers has resulted in images of N-acetyl aspartate in humans with spatial resolution of 360μl and signal-to-noise ratio ~7:1 in less than 13 min.

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalMagnetic Resonance in Medicine
Volume41
Issue number5
DOIs
StatePublished - 1999

Keywords

  • Chemical shift imaging
  • Echoplanar imaging
  • N-acetyl aspartate
  • Neurodegeneration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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