Abstract
A novel method of chemical shift imaging utilizing echoplanar imaging (EPI) has been developed for the purpose of improving the spatial resolution of metabolite images for the specific goal of high spatial resolution mapping of neuronal content. An EPI sequence was modified to allow temporal offsets of the 180°refocusing pulse that encode the chemical shift information into the phase of the signal. Implementation of this method on 1.5 and 3 T human imagers has resulted in images of N-acetyl aspartate in humans with spatial resolution of 360μl and signal-to-noise ratio ~7:1 in less than 13 min.
Original language | English (US) |
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Pages (from-to) | 877-882 |
Number of pages | 6 |
Journal | Magnetic Resonance in Medicine |
Volume | 41 |
Issue number | 5 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Chemical shift imaging
- Echoplanar imaging
- N-acetyl aspartate
- Neurodegeneration
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging