TY - JOUR
T1 - Echocardiographic detection of large left to right shunts and cardiomyopathies in infants and children
AU - Sahn, David J.
AU - Vaucher, Yvonne
AU - Williams, David E.
AU - Allen, Hugh D.
AU - Goldberg, Stanley J.
AU - Friedman, William F.
N1 - Funding Information:
From the Departments of Pediatrics (Cardiology), University of California at San Diego, La Jolla, Calif.’ and the University of Arizona, Tucson, Ark.+ Manuscript received June 30, 1975; revised manuscript received October 20, 1975, accepted October 22, 1975. t Recipient of U. S. Public Health Service Research Career Development Award I-KCHL 41737 from the National Heart and Lung Institute. National Institutes of Health, Bethesda, Md.
PY - 1976/7
Y1 - 1976/7
N2 - Diagnostic separation of infants with signs of cardiac failure (hypoglycemia, sepsis, myocarditis, hypoxemia) but no congenital cardiocirculatory malformation from those with a large left to right shunt is crucial in newborn management. Echocardiographic studies of 218 infants and children allowed group separation and distinction from normal by the assessment of mean velocity of circumferential fiber shortening (Vcf) and the ratio of left atrial to aortic root diameter at end-systole ( LA Ao). In normal premature and full-term infants, Vcf (1.51 ± 0.04 [mean ± standard error]) was significantly lower than in infants with a large shunt (2.12 ± 0.08, P < 0.01) and higher than in infants with nonstructural heart disease (1.18 ± 0.06, P < 0.001). LA Ao ratios were comparable in the groups with a large shunt and nonstructural heart disease (1.14 ± 0.1 and 1.26 ± 0.2, respectively) and were significantly higher in both groups than in normal subjects (0.77 ± 0.01, P < 0.001). Similar echocardiographic distinctions could be made when 10 older children (aged 2 to 10 years) with cardiomyopathy were compared with 45 normal older children. Serial determination of these variables was of major assistance in patient management.
AB - Diagnostic separation of infants with signs of cardiac failure (hypoglycemia, sepsis, myocarditis, hypoxemia) but no congenital cardiocirculatory malformation from those with a large left to right shunt is crucial in newborn management. Echocardiographic studies of 218 infants and children allowed group separation and distinction from normal by the assessment of mean velocity of circumferential fiber shortening (Vcf) and the ratio of left atrial to aortic root diameter at end-systole ( LA Ao). In normal premature and full-term infants, Vcf (1.51 ± 0.04 [mean ± standard error]) was significantly lower than in infants with a large shunt (2.12 ± 0.08, P < 0.01) and higher than in infants with nonstructural heart disease (1.18 ± 0.06, P < 0.001). LA Ao ratios were comparable in the groups with a large shunt and nonstructural heart disease (1.14 ± 0.1 and 1.26 ± 0.2, respectively) and were significantly higher in both groups than in normal subjects (0.77 ± 0.01, P < 0.001). Similar echocardiographic distinctions could be made when 10 older children (aged 2 to 10 years) with cardiomyopathy were compared with 45 normal older children. Serial determination of these variables was of major assistance in patient management.
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U2 - 10.1016/0002-9149(76)90065-5
DO - 10.1016/0002-9149(76)90065-5
M3 - Article
AN - SCOPUS:0017118864
SN - 0002-9149
VL - 38
SP - 73
EP - 79
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 1
ER -