EBV noncoding RNAs

Rebecca Skalsky, Bryan R. Cullen

Research output: Chapter in Book/Report/Conference proceedingChapter

27 Citations (Scopus)

Abstract

EBV expresses a number of viral noncoding RNAs (ncRNAs) during latent infection, many of which have known regulatory functions and can posttranscriptionally regulate viral and/or cellular gene expression. With recent advances in RNA sequencing technologies, the list of identified EBV ncRNAs continues to grow. EBV-encoded RNAs (EBERs), the BamHI-A rightward transcripts (BARTs), a small nucleolar RNA (snoRNA), and viral microRNAs (miRNAs) are all expressed during EBV infection in a variety of cell types and tumors. Recently, additional novel EBV ncRNAs have been identified. Viral miRNAs, in particular, have been under extensive investigation since their initial identification over ten years ago. High-throughput studies to capture miRNA targets have revealed a number of miRNA-regulated viral and cellular transcripts that tie into important biological networks. Functions for many EBV ncRNAs are still unknown; however, roles for many EBV miRNAs in latency and in tumorigenesis have begun to emerge. Ongoing mechanistic studies to elucidate the functions of EBV ncRNAs should unravel additional roles for ncRNAs in the viral life cycle. In this chapter, we will discuss our current knowledge of the types of ncRNAs expressed by EBV, their potential roles in viral latency, and their potential involvement in viral pathogenesis.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages181-217
Number of pages37
Volume391
DOIs
StatePublished - Oct 1 2015

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume391
ISSN (Print)0070217X
ISSN (Electronic)21969965

Fingerprint

Untranslated RNA
Human Herpesvirus 4
MicroRNAs
Small Nucleolar RNA
Virus Latency
RNA Sequence Analysis
Epstein-Barr Virus Infections
Viral RNA
Life Cycle Stages
Carcinogenesis
RNA
Technology
Gene Expression
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Skalsky, R., & Cullen, B. R. (2015). EBV noncoding RNAs. In Current Topics in Microbiology and Immunology (Vol. 391, pp. 181-217). (Current Topics in Microbiology and Immunology; Vol. 391). Springer Verlag. https://doi.org/10.1007/978-3-319-22834-1_6

EBV noncoding RNAs. / Skalsky, Rebecca; Cullen, Bryan R.

Current Topics in Microbiology and Immunology. Vol. 391 Springer Verlag, 2015. p. 181-217 (Current Topics in Microbiology and Immunology; Vol. 391).

Research output: Chapter in Book/Report/Conference proceedingChapter

Skalsky, R & Cullen, BR 2015, EBV noncoding RNAs. in Current Topics in Microbiology and Immunology. vol. 391, Current Topics in Microbiology and Immunology, vol. 391, Springer Verlag, pp. 181-217. https://doi.org/10.1007/978-3-319-22834-1_6
Skalsky R, Cullen BR. EBV noncoding RNAs. In Current Topics in Microbiology and Immunology. Vol. 391. Springer Verlag. 2015. p. 181-217. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-319-22834-1_6
Skalsky, Rebecca ; Cullen, Bryan R. / EBV noncoding RNAs. Current Topics in Microbiology and Immunology. Vol. 391 Springer Verlag, 2015. pp. 181-217 (Current Topics in Microbiology and Immunology).
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