Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles

Kimberly Ann V. Zubris, Onkar V. Khullar, Aaron P. Griset, Summer Gibbs-Strauss, John V. Frangioni, Yolonda L. Colson, Mark W. Grinstaff

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base-catalyzed free-radical polymerization method. The particles (1 = 5 0 nm), loaded with a dye (IR-786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig. (Chemical Equation Presented)

Original languageEnglish (US)
Pages (from-to)1435-1438
Number of pages4
JournalChemMedChem
Volume5
Issue number9
DOIs
StatePublished - Sep 3 2010
Externally publishedYes

Keywords

  • Drug delivery
  • Imaging agents
  • Nanoparticles
  • Polymerization
  • Redox chemistry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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