Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles

Kimberly Ann V. Zubris; Onkar V. Khullar; Aaron P. Griset; Summer Gibbs-Strauss; John V. Frangioni; Yolonda L. Colson; Mark W. Grinstaff

doi:10.1002/cmdc.201000250

Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles

Kimberly Ann V. Zubris, Onkar V. Khullar, Aaron P. Griset, Summer Gibbs-Strauss, John V. Frangioni, Yolonda L. Colson, Mark W. Grinstaff

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base-catalyzed free-radical polymerization method. The particles (1 = 5 0 nm), loaded with a dye (IR-786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig. (Chemical Equation Presented)

Original language	English (US)
Pages (from-to)	1435-1438
Number of pages	4
Journal	ChemMedChem
Volume	5
Issue number	9
DOIs	https://doi.org/10.1002/cmdc.201000250
State	Published - Sep 3 2010
Externally published	Yes

Keywords

Drug delivery
Imaging agents
Nanoparticles
Polymerization
Redox chemistry

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1002/cmdc.201000250

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abstract = "Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base-catalyzed free-radical polymerization method. The particles (1 = 5 0 nm), loaded with a dye (IR-786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig. (Chemical Equation Presented)",

keywords = "Drug delivery, Imaging agents, Nanoparticles, Polymerization, Redox chemistry",

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AU - Zubris, Kimberly Ann V.

AU - Khullar, Onkar V.

AU - Griset, Aaron P.

AU - Gibbs-Strauss, Summer

AU - Frangioni, John V.

AU - Colson, Yolonda L.

AU - Grinstaff, Mark W.

PY - 2010/9/3

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N2 - Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base-catalyzed free-radical polymerization method. The particles (1 = 5 0 nm), loaded with a dye (IR-786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig. (Chemical Equation Presented)

AB - Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base-catalyzed free-radical polymerization method. The particles (1 = 5 0 nm), loaded with a dye (IR-786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig. (Chemical Equation Presented)

KW - Drug delivery

KW - Imaging agents

KW - Nanoparticles

KW - Polymerization

KW - Redox chemistry

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Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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