Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion

Jeremy G. Perkins, Martin Schreiber, Charles E. Wade, John B. Holcomb

    Research output: Contribution to journalArticle

    91 Citations (Scopus)

    Abstract

    BACKGROUND: Coagulopathy is a consequence of severe trauma, especially in massively transfused patients (≥10 units of red blood cells in 24 hours), and is associated with increased mortality. We hypothesized that recombinant factor VIIa (rFVIIa) administered to massive transfusion patients before transfusion of 8 units of blood (early) would reduce transfusion requirements compared with rFVIIa after 8 units (late). METHODS: We retrospectively reviewed records for trauma admissions to combat support hospitals in Iraq between January 2004 and October 2005. Patients requiring a massive transfusion and receiving rFVIIa were identified. Groups were divided into those who received rFVIIa early or late. RESULTS: Of 5,334 trauma patients (civilian and military), 365 (6.8%) required massive transfusion. Of these, 117 (32%) received rFVIIa. Complete records for blood transfusions were available for 61 patients: 90% had penetrating trauma, 17 received rFVIIa early, and 44 received it late. At admission, temperature, heart rate, blood pressure, Glasgow Coma Scale score, base deficit, hemoglobin, platelets, prothrombin time/International Normalized Ratio, and Injury Severity Score were similar in both groups as were administered units of fresh frozen plasma, fresh whole blood, cryoprecipitate (cryo), and crystalloid. The early rFVIIa group required fewer units of blood during the first 24-hour period (mean 20.6 vs. 25.7, p = 0.048) and fewer units of stored red blood cells (mean 16.7 vs. 21.7, p = 0.049). Early and late mortality (33.3% vs. 34.2%, p = NS), acute respiratory distress syndrome (5.9 vs. 6.8%, p = NS), infection (5.9% vs. 9.1%, p = NS), and thrombotic events (0% vs. 2.3%, p = NS) were similar. CONCLUSIONS: Early administration of rFVIIa decreased red blood cell use by 20% in trauma patients requiring massive transfusion.

    Original languageEnglish (US)
    Pages (from-to)1095-1099
    Number of pages5
    JournalJournal of Trauma - Injury, Infection and Critical Care
    Volume62
    Issue number5
    DOIs
    StatePublished - May 2007

    Fingerprint

    Wounds and Injuries
    Erythrocytes
    Iraq
    Glasgow Coma Scale
    Injury Severity Score
    International Normalized Ratio
    Mortality
    recombinant FVIIa
    Prothrombin Time
    Adult Respiratory Distress Syndrome
    Blood Transfusion
    Hemoglobins
    Blood Platelets
    Heart Rate
    Blood Pressure
    Temperature
    Infection

    Keywords

    • Blood transfusion
    • Coagulopathy
    • Combat
    • Massive transfusion
    • Penetrating
    • Recombinant factor VIIa
    • Trauma

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion. / Perkins, Jeremy G.; Schreiber, Martin; Wade, Charles E.; Holcomb, John B.

    In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 62, No. 5, 05.2007, p. 1095-1099.

    Research output: Contribution to journalArticle

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    abstract = "BACKGROUND: Coagulopathy is a consequence of severe trauma, especially in massively transfused patients (≥10 units of red blood cells in 24 hours), and is associated with increased mortality. We hypothesized that recombinant factor VIIa (rFVIIa) administered to massive transfusion patients before transfusion of 8 units of blood (early) would reduce transfusion requirements compared with rFVIIa after 8 units (late). METHODS: We retrospectively reviewed records for trauma admissions to combat support hospitals in Iraq between January 2004 and October 2005. Patients requiring a massive transfusion and receiving rFVIIa were identified. Groups were divided into those who received rFVIIa early or late. RESULTS: Of 5,334 trauma patients (civilian and military), 365 (6.8{\%}) required massive transfusion. Of these, 117 (32{\%}) received rFVIIa. Complete records for blood transfusions were available for 61 patients: 90{\%} had penetrating trauma, 17 received rFVIIa early, and 44 received it late. At admission, temperature, heart rate, blood pressure, Glasgow Coma Scale score, base deficit, hemoglobin, platelets, prothrombin time/International Normalized Ratio, and Injury Severity Score were similar in both groups as were administered units of fresh frozen plasma, fresh whole blood, cryoprecipitate (cryo), and crystalloid. The early rFVIIa group required fewer units of blood during the first 24-hour period (mean 20.6 vs. 25.7, p = 0.048) and fewer units of stored red blood cells (mean 16.7 vs. 21.7, p = 0.049). Early and late mortality (33.3{\%} vs. 34.2{\%}, p = NS), acute respiratory distress syndrome (5.9 vs. 6.8{\%}, p = NS), infection (5.9{\%} vs. 9.1{\%}, p = NS), and thrombotic events (0{\%} vs. 2.3{\%}, p = NS) were similar. CONCLUSIONS: Early administration of rFVIIa decreased red blood cell use by 20{\%} in trauma patients requiring massive transfusion.",
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    AU - Perkins, Jeremy G.

    AU - Schreiber, Martin

    AU - Wade, Charles E.

    AU - Holcomb, John B.

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    N2 - BACKGROUND: Coagulopathy is a consequence of severe trauma, especially in massively transfused patients (≥10 units of red blood cells in 24 hours), and is associated with increased mortality. We hypothesized that recombinant factor VIIa (rFVIIa) administered to massive transfusion patients before transfusion of 8 units of blood (early) would reduce transfusion requirements compared with rFVIIa after 8 units (late). METHODS: We retrospectively reviewed records for trauma admissions to combat support hospitals in Iraq between January 2004 and October 2005. Patients requiring a massive transfusion and receiving rFVIIa were identified. Groups were divided into those who received rFVIIa early or late. RESULTS: Of 5,334 trauma patients (civilian and military), 365 (6.8%) required massive transfusion. Of these, 117 (32%) received rFVIIa. Complete records for blood transfusions were available for 61 patients: 90% had penetrating trauma, 17 received rFVIIa early, and 44 received it late. At admission, temperature, heart rate, blood pressure, Glasgow Coma Scale score, base deficit, hemoglobin, platelets, prothrombin time/International Normalized Ratio, and Injury Severity Score were similar in both groups as were administered units of fresh frozen plasma, fresh whole blood, cryoprecipitate (cryo), and crystalloid. The early rFVIIa group required fewer units of blood during the first 24-hour period (mean 20.6 vs. 25.7, p = 0.048) and fewer units of stored red blood cells (mean 16.7 vs. 21.7, p = 0.049). Early and late mortality (33.3% vs. 34.2%, p = NS), acute respiratory distress syndrome (5.9 vs. 6.8%, p = NS), infection (5.9% vs. 9.1%, p = NS), and thrombotic events (0% vs. 2.3%, p = NS) were similar. CONCLUSIONS: Early administration of rFVIIa decreased red blood cell use by 20% in trauma patients requiring massive transfusion.

    AB - BACKGROUND: Coagulopathy is a consequence of severe trauma, especially in massively transfused patients (≥10 units of red blood cells in 24 hours), and is associated with increased mortality. We hypothesized that recombinant factor VIIa (rFVIIa) administered to massive transfusion patients before transfusion of 8 units of blood (early) would reduce transfusion requirements compared with rFVIIa after 8 units (late). METHODS: We retrospectively reviewed records for trauma admissions to combat support hospitals in Iraq between January 2004 and October 2005. Patients requiring a massive transfusion and receiving rFVIIa were identified. Groups were divided into those who received rFVIIa early or late. RESULTS: Of 5,334 trauma patients (civilian and military), 365 (6.8%) required massive transfusion. Of these, 117 (32%) received rFVIIa. Complete records for blood transfusions were available for 61 patients: 90% had penetrating trauma, 17 received rFVIIa early, and 44 received it late. At admission, temperature, heart rate, blood pressure, Glasgow Coma Scale score, base deficit, hemoglobin, platelets, prothrombin time/International Normalized Ratio, and Injury Severity Score were similar in both groups as were administered units of fresh frozen plasma, fresh whole blood, cryoprecipitate (cryo), and crystalloid. The early rFVIIa group required fewer units of blood during the first 24-hour period (mean 20.6 vs. 25.7, p = 0.048) and fewer units of stored red blood cells (mean 16.7 vs. 21.7, p = 0.049). Early and late mortality (33.3% vs. 34.2%, p = NS), acute respiratory distress syndrome (5.9 vs. 6.8%, p = NS), infection (5.9% vs. 9.1%, p = NS), and thrombotic events (0% vs. 2.3%, p = NS) were similar. CONCLUSIONS: Early administration of rFVIIa decreased red blood cell use by 20% in trauma patients requiring massive transfusion.

    KW - Blood transfusion

    KW - Coagulopathy

    KW - Combat

    KW - Massive transfusion

    KW - Penetrating

    KW - Recombinant factor VIIa

    KW - Trauma

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