Early tumor growth between initial resection and radiotherapy of glioblastoma: incidence and impact on clinical outcomes

Javier E. Villanueva-Meyer, Seunggu (Jude) Han, Soonmee Cha, Nicholas A. Butowski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Early tumor growth, or increased contrast-enhancing tumor not related to evolving post-surgical injury, in the interval between surgical resection and initiation of radiotherapy has implications for treatment planning and clinical outcomes. In this study we evaluated the incidence of early tumor growth, correlated tumor growth with survival outcome measures, and assessed predictors of early tumor growth in glioblastoma. We reviewed the records of patients with newly-diagnosed glioblastoma who underwent surgical resection and chemoradiotherapy at our institution. Patients with preoperative, immediate postoperative, and preradiotherapy MRI were included. Conventional MRI and DWI features were assessed. The correlation between early tumor growth and extent of resection with survival was assessed with Kaplan–Meier analysis. Logistic regression was carried out to evaluate predictors of early tumor growth. Of 140 included patients, sixty-seven cases (48%) had new or increased contrast enhancement attributed to early tumor growth. Median progression free survival (PFS) and overall survival (OS) were shorter in patients with early tumor growth compared to those without early tumor growth (p < 0.001 for both). Additionally, PFS and OS were longer in patients who underwent gross total resection of enhancing tumor (p = 0.016 and <0.001, respectively). Of the evaluated predictors of early growth, subtotal resection was most likely to result in early growth (p < 0.001). Imaging evidence of early tumor growth is often observed at preradiotherapy MRI and is associated with shorter survival. Gross total resection of contrast enhancing tumor decreases likelihood of early tumor growth.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalJournal of Neuro-Oncology
Volume134
Issue number1
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Glioblastoma
Radiotherapy
Incidence
Growth
Neoplasms
Survival
Disease-Free Survival
Intraoperative Complications
Chemoradiotherapy
Cohort Studies
Logistic Models

Keywords

  • Extent of resection
  • Glioblastoma
  • Radiotherapy
  • Tumor regrowth

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Early tumor growth between initial resection and radiotherapy of glioblastoma : incidence and impact on clinical outcomes. / Villanueva-Meyer, Javier E.; Han, Seunggu (Jude); Cha, Soonmee; Butowski, Nicholas A.

In: Journal of Neuro-Oncology, Vol. 134, No. 1, 01.08.2017, p. 213-219.

Research output: Contribution to journalArticle

Villanueva-Meyer, Javier E. ; Han, Seunggu (Jude) ; Cha, Soonmee ; Butowski, Nicholas A. / Early tumor growth between initial resection and radiotherapy of glioblastoma : incidence and impact on clinical outcomes. In: Journal of Neuro-Oncology. 2017 ; Vol. 134, No. 1. pp. 213-219.
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